Research output: Contribution to journal › Article › peer-review
Иммуногистохимическое исследование MSH2, PMS2, MLH1, MSH6 в сопоставлении с анализом микросателлитной нестабильности в аденокарциноме толстой кишки. / Raskin, G. A.; Yanus, G. A.; Kornilov, A. V.; Orlova, R. V.; Petrov, S. V.; Protasova, A. E.; Pozharisski, K. M.; Imyanitov, E. N.
In: Вопросы онкологии, Vol. 60, No. 2, 2014, p. 47-50.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Иммуногистохимическое исследование MSH2, PMS2, MLH1, MSH6 в сопоставлении с анализом микросателлитной нестабильности в аденокарциноме толстой кишки
AU - Raskin, G. A.
AU - Yanus, G. A.
AU - Kornilov, A. V.
AU - Orlova, R. V.
AU - Petrov, S. V.
AU - Protasova, A. E.
AU - Pozharisski, K. M.
AU - Imyanitov, E. N.
N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Adenocarcinoma of the colon in 10-20% is associated with microsatellite instability, which can occur both in sporadic cancers and in hereditary nonpolyposis colon cancer. Our analysis of 195 cases of adenocarcinoma of the colon showed that microsatellite instability (MSI-H) was found only in 1.5% of patients. Subsequent choice of patients with suspected hereditary Lynch syndrome led to the identification of additional 17 patients with microsatellite instability. They passed an analysis of genes of repair system of unpaired nucleotides of DNA. The study showed that immunohistochemical staining of MSH2, MSH6, MLH1, PMS2 could effectively conduct a preliminary screening of the Lynch syndrome but was unable to divide cases of sporadic and hereditary MSI-H colon cancer.
AB - Adenocarcinoma of the colon in 10-20% is associated with microsatellite instability, which can occur both in sporadic cancers and in hereditary nonpolyposis colon cancer. Our analysis of 195 cases of adenocarcinoma of the colon showed that microsatellite instability (MSI-H) was found only in 1.5% of patients. Subsequent choice of patients with suspected hereditary Lynch syndrome led to the identification of additional 17 patients with microsatellite instability. They passed an analysis of genes of repair system of unpaired nucleotides of DNA. The study showed that immunohistochemical staining of MSH2, MSH6, MLH1, PMS2 could effectively conduct a preliminary screening of the Lynch syndrome but was unable to divide cases of sporadic and hereditary MSI-H colon cancer.
KW - Microsatellite instability
KW - MLH1
KW - MSH2
KW - MSH6
KW - PMS2
UR - http://www.scopus.com/inward/record.url?scp=84902837353&partnerID=8YFLogxK
U2 - 10.37469/0507-3758-2014-60-2-47-50
DO - 10.37469/0507-3758-2014-60-2-47-50
M3 - статья
C2 - 24919261
AN - SCOPUS:84902837353
VL - 60
SP - 47
EP - 50
JO - Вопросы онкологии
JF - Вопросы онкологии
SN - 0507-3758
IS - 2
ER -
ID: 34886744