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Using Fura-2AM microfluorimetry it was shown for the first time that phospholipase A2 inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednizolon and dexamethazone attenuate Ca+ 2 responses, induced by neuroleptic chlorpromazine, in macrophages. The results suggest the involvement of phospholipase A2 and arachidonic acid metabolism cascade in the effect of chlorpromazine on intracellular Ca+ 2 concentration in macrophages.
Translated title of the contributionPHOSPHOLIPASE A2 INHIBITORS ATTENUATE CA+ 2 RESPONSES INDUCED BY CHLORPROMAZINE IN MACROPHAGES
Original languageRussian
Title of host publicationМатериалы XXIII съезда Физиологического общества имени И.П. Павлова
Place of PublicationВоронеж
PublisherИСТОКИ
Pages434-436
StatePublished - 2017
EventXXIII съезд Физиологического общества им. И. П. Павлова - Воронеж, Russian Federation
Duration: 18 Sep 2017 → 22 Sep 2017
Conference number: XXIII
http://vrngmu.ru/academy/events/xxiii-sezd-fiziologicheskogo-obshchestva-im-i-p-pavlova/

Conference

ConferenceXXIII съезд Физиологического общества им. И. П. Павлова
Country/TerritoryRussian Federation
CityВоронеж
Period18/09/17 → 22/09/17
Internet address

    Research areas

  • macrophages, chlorpromazine, phospholipase A2, intracellular Ca+ 2 concentration

ID: 77861735