Prepulse inhibition (PPI) is considered as endophenotypes in schizophrenia, which allows applications of PPI in animal models, both for revealing pharmacological effects and for finding out the mechanisms of functioning of neural networks. Recently, much attention has been paid to the study of the so-called TAARs (TAAR1-TAAR9) of trace amine receptors, can be related to the pathogenesis of various types of neuropsychiatric disorders, including schizophrenia. The experiments were conducted on male mice C57BL / 6 (n = 16), wild type WT (n = 29) and TAAR1 knockout mice (KO) (n = 19). WT and KO were derived from 129S1/Sv and C57BL/6. Our results suggest that the prepulse inhibition is well expressed in all the strains studied. In addition, the response amplitude to the stimulus (SS) in the stimulus pair with prestimulus (PP- SS) in the KO strain animals is significantly higher than the response in the WT line animals. TAAR1 knockout mice (KO) exhibited prepulse inhibition (PPI) impairment.