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АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A. / Shpakova, V. S.; Avdeeva, A.; Al Arawe, N.; Prilepskaya, A. M.; Gambaryan, S. P.; Alekseeva, E. S.; Rukoyatkina, Natalia.

In: Биологические мембраны, Vol. 38, No. 6, 2021, p. 464-473.

Research output: Contribution to journal › Article › peer-review

Harvard

Shpakova, VS, Avdeeva, A, Al Arawe, N, Prilepskaya, AM, Gambaryan, SP, Alekseeva, ES & Rukoyatkina, N 2021, 'АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A', Биологические мембраны, vol. 38, no. 6, pp. 464-473. https://doi.org/10.31857/S0233475521060104

APA

Shpakova, V. S., Avdeeva, A., Al Arawe, N., Prilepskaya, A. M., Gambaryan, S. P., Alekseeva, E. S., & Rukoyatkina, N. (2021). АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A. Биологические мембраны, 38(6), 464-473. https://doi.org/10.31857/S0233475521060104

Vancouver

Shpakova VS, Avdeeva A, Al Arawe N, Prilepskaya AM, Gambaryan SP, Alekseeva ES et al. АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A. Биологические мембраны. 2021;38(6):464-473. https://doi.org/10.31857/S0233475521060104

Author

Shpakova, V. S. ; Avdeeva, A. ; Al Arawe, N. ; Prilepskaya, A. M. ; Gambaryan, S. P. ; Alekseeva, E. S. ; Rukoyatkina, Natalia. / АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A. In: Биологические мембраны. 2021 ; Vol. 38, No. 6. pp. 464-473.

BibTeX

@article{940304123a264a078cd0bbcbffc4c145,
title = "АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A",
abstract = "Nobiletin is a polymethoxylated flavone isolated from citrus peels which possesses a wide range of beneficial effects. Specifically, nobiletin exerts anti-inflammatory, antibacterial, and antioxidant effects. Recent research showed that nobiletin is able to diminish platelet adhesion and aggregation, indicating this compound as a potential therapeutic drug in thrombosis therapy. However, the exact mechanism of nobiletin action on platelets is unclear. Hence, the main goal of our study was to investigate the molecular mechanism of nobiletin-induced platelet inhibition. We demonstrated that nobiletin blocks induced platelet activation and does not cause platelet apoptosis. Inhibition effect of nobiletin on platelets at least partly is mediated by activation of A(2A) adenosine receptor and consequent AC/cAMP/PKA signaling pathway activation.",
keywords = "platelets, nobiletin, antiplatelet therapy, adenosine monophosphate (AMP), guanosine mono phosphate (cGMP), PICA, PKG, adenosine receptor, VASODILATOR-STIMULATED PHOSPHOPROTEIN, NITRIC-OXIDE, L-ARGININE, IN-VITRO, PLATELETS, THROMBOSIS, MODULATION, MECHANISM, APOPTOSIS",
author = "Shpakova, {V. S.} and A. Avdeeva and {Al Arawe}, N. and Prilepskaya, {A. M.} and Gambaryan, {S. P.} and Alekseeva, {E. S.} and Natalia Rukoyatkina",
year = "2021",
doi = "10.31857/S0233475521060104",
language = "русский",
volume = "38",
pages = "464--473",
journal = "БИОЛОГИЧЕСКИЕ МЕМБРАНЫ: ЖУРНАЛ МЕМБРАННОЙ И КЛЕТОЧНОЙ БИОЛОГИИ",
issn = "0233-4755",
publisher = "Российская академия наук",
number = "6",

}

RIS

TY - JOUR

T1 - АНТИТРОМБОЦИТАРНЫЙ ЭФФЕКТ НОБИЛЕТИНА ОПОСРЕДОВАН АКТИВАЦИЕЙ АДЕНОЗИНОВОГО РЕЦЕПТОРА A2A

AU - Shpakova, V. S.

AU - Avdeeva, A.

AU - Al Arawe, N.

AU - Prilepskaya, A. M.

AU - Gambaryan, S. P.

AU - Alekseeva, E. S.

AU - Rukoyatkina, Natalia

PY - 2021

Y1 - 2021

N2 - Nobiletin is a polymethoxylated flavone isolated from citrus peels which possesses a wide range of beneficial effects. Specifically, nobiletin exerts anti-inflammatory, antibacterial, and antioxidant effects. Recent research showed that nobiletin is able to diminish platelet adhesion and aggregation, indicating this compound as a potential therapeutic drug in thrombosis therapy. However, the exact mechanism of nobiletin action on platelets is unclear. Hence, the main goal of our study was to investigate the molecular mechanism of nobiletin-induced platelet inhibition. We demonstrated that nobiletin blocks induced platelet activation and does not cause platelet apoptosis. Inhibition effect of nobiletin on platelets at least partly is mediated by activation of A(2A) adenosine receptor and consequent AC/cAMP/PKA signaling pathway activation.

AB - Nobiletin is a polymethoxylated flavone isolated from citrus peels which possesses a wide range of beneficial effects. Specifically, nobiletin exerts anti-inflammatory, antibacterial, and antioxidant effects. Recent research showed that nobiletin is able to diminish platelet adhesion and aggregation, indicating this compound as a potential therapeutic drug in thrombosis therapy. However, the exact mechanism of nobiletin action on platelets is unclear. Hence, the main goal of our study was to investigate the molecular mechanism of nobiletin-induced platelet inhibition. We demonstrated that nobiletin blocks induced platelet activation and does not cause platelet apoptosis. Inhibition effect of nobiletin on platelets at least partly is mediated by activation of A(2A) adenosine receptor and consequent AC/cAMP/PKA signaling pathway activation.

KW - platelets

KW - nobiletin

KW - antiplatelet therapy

KW - adenosine monophosphate (AMP)

KW - guanosine mono phosphate (cGMP)

KW - PICA

KW - PKG

KW - adenosine receptor

KW - VASODILATOR-STIMULATED PHOSPHOPROTEIN

KW - NITRIC-OXIDE

KW - L-ARGININE

KW - IN-VITRO

KW - PLATELETS

KW - THROMBOSIS

KW - MODULATION

KW - MECHANISM

KW - APOPTOSIS

UR - https://www.elibrary.ru/sewdva

U2 - 10.31857/S0233475521060104

DO - 10.31857/S0233475521060104

M3 - статья

VL - 38

SP - 464

EP - 473

JO - БИОЛОГИЧЕСКИЕ МЕМБРАНЫ: ЖУРНАЛ МЕМБРАННОЙ И КЛЕТОЧНОЙ БИОЛОГИИ

JF - БИОЛОГИЧЕСКИЕ МЕМБРАНЫ: ЖУРНАЛ МЕМБРАННОЙ И КЛЕТОЧНОЙ БИОЛОГИИ

SN - 0233-4755

IS - 6

ER -

ID: 107837498