With the use of the voltage-clamp technique the involvement of the lipoxygenase oxidation pathway of arachidonic acid in the effect of immunomodulator glutoxim on Na+ transport in frog skin was investigated. It was shown that the inhibitor of all known types of lipoxygenases nordihydroguaiaretic acid decreases the stimulatory effect of glutoxim on Na+ transport in frog skin. The results suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid in glutoxim effect on Na+ transport in frog skin