One of the greatest physicists of the twentieth century, Nobel Prize winner Wolfgang Pauli, at the age of about 30, experienced a serious life crisis. The creator of analytical psychology Carl Gustav Jung helped him out of it. As a result, Pauli and Jung became close and for almost thirty years thought together about creating such a holistic scientific picture of the world that would be able to describe inextricable unity along with physical and psychical reality. Today, the problems raised by Pauli and Jung are attracting more and more attention of researchers since the most important scientific and technological challenge of our time is the study of the brain and consciousness. The experience of the interaction of two prominent researchers can become one of the growth points of an interdisciplinary research program, in the context of which it will be possible to organically combine two opposing and at the same time complementing each other views – a detached-objective view of the world ―from the outside‖ and an existential-subjective view ―from the inside‖, allowing to describe both sides of reality – quantitative and qualitative, and thus answer the most important challenges of our time – come close to resolving the ―hard problem‖ of consciousness and ending the second quantum revolution