Research output: Contribution to journal › Article › peer-review
Возможность прогнозирования эффективности терапии у больных впервые выявленным инфильтративным туберкулезом легких по исходной активности аденозиндезаминазы и показателей воспалительного ответа. / Дьякова , Марина Евгеньевна ; Алексеева, Нина Петровна; Эсмедляева , Диляра Салиевна; Яблонский, Петр Казимирович.
In: ТУБЕРКУЛЕЗ И БОЛЕЗНИ ЛЕГКИХ, Vol. 100, No. 5, 09.06.2022, p. 28-34.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Возможность прогнозирования эффективности терапии у больных впервые выявленным инфильтративным туберкулезом легких по исходной активности аденозиндезаминазы и показателей воспалительного ответа
AU - Дьякова , Марина Евгеньевна
AU - Алексеева, Нина Петровна
AU - Эсмедляева , Диляра Салиевна
AU - Яблонский, Петр Казимирович
PY - 2022/6/9
Y1 - 2022/6/9
N2 - The objective: to evaluate the possibility of using the baseline activity of adenosine deaminase (ADA) to predict effectiveness of therapy in patients with new infiltrative pulmonary tuberculosis (IPTB). Subjects and Methods. Data of 121 patients with new infiltrative pulmonary tuberculosis were analyzed; patients were divided into groups according to therapy effectiveness. Results., The discriminant analysis of data of new infiltrative pulmonary tuberculosis patients made it possible to obtain a discriminant function which included the activity of ADA, the concentration of haptoglobin (HP) and ceruloplasmin (CP) - parameters reflecting that severity of the disease and protective potential of the host. Conclusion. Analysis of ADA activity in combination with level of HP and CP allows the following: predicting effectiveness of the intensive phase of therapy before it begins in patients with new infiltrative pulmonary tuberculosis (with the accuracy of 77.0%); assuming that the reduction of ADA activity and inhibition of the inflammatory response may be useful for treatment of patients with new infiltrative pulmonary tuberculosis.
AB - The objective: to evaluate the possibility of using the baseline activity of adenosine deaminase (ADA) to predict effectiveness of therapy in patients with new infiltrative pulmonary tuberculosis (IPTB). Subjects and Methods. Data of 121 patients with new infiltrative pulmonary tuberculosis were analyzed; patients were divided into groups according to therapy effectiveness. Results., The discriminant analysis of data of new infiltrative pulmonary tuberculosis patients made it possible to obtain a discriminant function which included the activity of ADA, the concentration of haptoglobin (HP) and ceruloplasmin (CP) - parameters reflecting that severity of the disease and protective potential of the host. Conclusion. Analysis of ADA activity in combination with level of HP and CP allows the following: predicting effectiveness of the intensive phase of therapy before it begins in patients with new infiltrative pulmonary tuberculosis (with the accuracy of 77.0%); assuming that the reduction of ADA activity and inhibition of the inflammatory response may be useful for treatment of patients with new infiltrative pulmonary tuberculosis.
KW - acute phase reactants
KW - adenosine deaminase
KW - predicting the effectiveness of therapy
KW - pulmonary tuberculosis
KW - acute phase reactants
KW - adenosine deaminase
KW - predicting the effectiveness of therapy
KW - pulmonary tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85141051733&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/de382b85-21ac-3052-b9a7-73bc3bf25a3b/
U2 - 10.21292/2075-1230-2022-100-5-28-34
DO - 10.21292/2075-1230-2022-100-5-28-34
M3 - статья
VL - 100
SP - 28
EP - 34
JO - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
JF - ПРОБЛЕМЫ ТУБЕРКУЛЕЗА И БОЛЕЗНЕЙ ЛЕГКИХ
SN - 1728-2993
IS - 5
ER -
ID: 100517579