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РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА. / Полякова, Виктория Олеговна; Пухальская, А.Э.; Сопромадзе , А.Г.; Медведев , Д.С.; Козлов, К.Л.; Кечаева, Е.И.

In: УСПЕХИ ГЕРОНТОЛОГИИ, Vol. 39, No. 2, 29.06.2026, p. 274-278.

Research output: Contribution to journal › Article › peer-review

Harvard

Полякова, ВО, Пухальская, АЭ, Сопромадзе , АГ, Медведев , ДС, Козлов, КЛ & Кечаева, ЕИ 2026, 'РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА', УСПЕХИ ГЕРОНТОЛОГИИ, vol. 39, no. 2, pp. 274-278. https://doi.org/10.34922/AE.2026.39.2.014

APA

Полякова, В. О., Пухальская, А. Э., Сопромадзе , А. Г., Медведев , Д. С., Козлов, К. Л., & Кечаева, Е. И. (2026). РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА. УСПЕХИ ГЕРОНТОЛОГИИ, 39(2), 274-278. https://doi.org/10.34922/AE.2026.39.2.014

Vancouver

Полякова ВО, Пухальская АЭ, Сопромадзе АГ, Медведев ДС, Козлов КЛ, Кечаева ЕИ. РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА. УСПЕХИ ГЕРОНТОЛОГИИ. 2026 Jun 29;39(2):274-278. https://doi.org/10.34922/AE.2026.39.2.014

Author

Полякова, Виктория Олеговна ; Пухальская, А.Э. ; Сопромадзе , А.Г. ; Медведев , Д.С. ; Козлов, К.Л. ; Кечаева, Е.И. / РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА. In: УСПЕХИ ГЕРОНТОЛОГИИ. 2026 ; Vol. 39, No. 2. pp. 274-278.

BibTeX

@article{39aab1517564469583df211d071721b1,
title = "РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА",
abstract = "Atherosclerosis is considered as one of the leading age-associated diseases, the development of which is closely related to disorders of lipid metabolism, chronic inflammation and activation of cellular aging mechanisms. During aging, the body undergoes a metabolic restructuring of lipid metabolism, which is accompanied by the accumulation of atherogenic lipids. These processes can be considered a molecular-cellular mechanism of vascular aging, contributing to the progression of atherosclerotic changes and age-related dysfunction of the vascular wall. The aim of the study is to investigate the relationship between lipid metabolism indicators (LDL, ApoB, oxLDL) and markers of cellular aging (CD36, p16INK4a, p53) in atherosclerosis in elderly and senile individuals. A comparative study was conducted involving 310 patients aged 60-89 years: 162 with clinically verified atherosclerosis and 148 individuals in the control group. Lipid metabolism was assessed using biochemical and immunoenzyme methods. The expression of CD36, p16INK4a, and p53 was determined using diagnostic immunocytochemistry of the buccal epithelium. In patients with atherosclerosis, there was a statistically significant increase in the levels of LDL, ApoB, and oxLDL (p",
keywords = "CD36, atherosclerosis, cellular aging, lipid metabolism, oxLDL, p16INK4a, p53, vascular aging",
author = "Полякова, {Виктория Олеговна} and А.Э. Пухальская and А.Г. Сопромадзе and Д.С. Медведев and К.Л. Козлов and Е.И. Кечаева",
year = "2026",
month = jun,
day = "29",
doi = "10.34922/AE.2026.39.2.014",
language = "русский",
volume = "39",
pages = "274--278",
journal = "УСПЕХИ ГЕРОНТОЛОГИИ",
issn = "1561-9125",
publisher = "Eskulap",
number = "2",

}

RIS

TY - JOUR

T1 - РОЛЬ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА В АКТИВАЦИИ МАРКЕРОВ КЛЕТОЧНОГО СТАРЕНИЯ ПРИ АТЕРОСКЛЕРОЗЕ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА

AU - Полякова, Виктория Олеговна

AU - Пухальская, А.Э.

AU - Сопромадзе , А.Г.

AU - Медведев , Д.С.

AU - Козлов, К.Л.

AU - Кечаева, Е.И.

PY - 2026/6/29

Y1 - 2026/6/29

N2 - Atherosclerosis is considered as one of the leading age-associated diseases, the development of which is closely related to disorders of lipid metabolism, chronic inflammation and activation of cellular aging mechanisms. During aging, the body undergoes a metabolic restructuring of lipid metabolism, which is accompanied by the accumulation of atherogenic lipids. These processes can be considered a molecular-cellular mechanism of vascular aging, contributing to the progression of atherosclerotic changes and age-related dysfunction of the vascular wall. The aim of the study is to investigate the relationship between lipid metabolism indicators (LDL, ApoB, oxLDL) and markers of cellular aging (CD36, p16INK4a, p53) in atherosclerosis in elderly and senile individuals. A comparative study was conducted involving 310 patients aged 60-89 years: 162 with clinically verified atherosclerosis and 148 individuals in the control group. Lipid metabolism was assessed using biochemical and immunoenzyme methods. The expression of CD36, p16INK4a, and p53 was determined using diagnostic immunocytochemistry of the buccal epithelium. In patients with atherosclerosis, there was a statistically significant increase in the levels of LDL, ApoB, and oxLDL (p

AB - Atherosclerosis is considered as one of the leading age-associated diseases, the development of which is closely related to disorders of lipid metabolism, chronic inflammation and activation of cellular aging mechanisms. During aging, the body undergoes a metabolic restructuring of lipid metabolism, which is accompanied by the accumulation of atherogenic lipids. These processes can be considered a molecular-cellular mechanism of vascular aging, contributing to the progression of atherosclerotic changes and age-related dysfunction of the vascular wall. The aim of the study is to investigate the relationship between lipid metabolism indicators (LDL, ApoB, oxLDL) and markers of cellular aging (CD36, p16INK4a, p53) in atherosclerosis in elderly and senile individuals. A comparative study was conducted involving 310 patients aged 60-89 years: 162 with clinically verified atherosclerosis and 148 individuals in the control group. Lipid metabolism was assessed using biochemical and immunoenzyme methods. The expression of CD36, p16INK4a, and p53 was determined using diagnostic immunocytochemistry of the buccal epithelium. In patients with atherosclerosis, there was a statistically significant increase in the levels of LDL, ApoB, and oxLDL (p

KW - CD36

KW - atherosclerosis

KW - cellular aging

KW - lipid metabolism

KW - oxLDL

KW - p16INK4a

KW - p53

KW - vascular aging

UR - https://www.mendeley.com/catalogue/6afa2ec5-9297-39c1-9630-3c491cd7ddd9/

U2 - 10.34922/AE.2026.39.2.014

DO - 10.34922/AE.2026.39.2.014

M3 - статья

VL - 39

SP - 274

EP - 278

JO - УСПЕХИ ГЕРОНТОЛОГИИ

JF - УСПЕХИ ГЕРОНТОЛОГИИ

SN - 1561-9125

IS - 2

ER -

ID: 162374427