Objective was to assess the efficacy of treatment of asthenic syndrome in surgical patients and sufferers with combined injuries by means of succinate containing metabolic protectors (emoxipine/mexidol, riboxine/cytoflavine, metaprot/metaprot plus). Methods. In 134 surgical patients and sufferers with combined injuries, an asthenic syndrome (high anxiety, depression, high psychic and physical tiredness, weakness, absent-mindedness, attention disorders, reduced physical and psychical ability, need in durative rest, high psychic exhaustion, social disadaptation) was revealed by clinical, psychological and instrumental methods. Results. Metabolic protectors containing (mexidol, cytoflavine, metaprot plus) or non-containing (emoxipine, riboxine, metaprot) succinate in their structure were clinically effective in abolition or reduction of the asthenic syndrome in such patients, succinate containing drugs being more effective. Antiasthenic action was represented by proper antiasthenic, antidepressant, anxiolytic, nootropic (cognitive) and positive general somatic effects of the drugs. Conclusion. Special correction of asthenic disorders is recommended in surgical patients and sufferers with combined injuries.