Research output: Contribution to journal › Article › peer-review
ВЫРАЖЕННОСТЬ СЕПТАЛЬНОЙ РЕДУКЦИИ И ИСХОДЫ ПОСЛЕ ЭТАНОЛОВОЙ СЕПТАЛЬНОЙ АБЛАЦИИ У ПАЦИЕНТОВ С ОБСТРУКТИВНОЙ ГИПЕРТРОФИЧЕСКОЙ КАРДИОМИОПАТИЕЙ. / Shloydo, E. A.; Kashtanov, M. G.; Popov, K. V.; Sergeev, A. S.; Maznev, D. S.; Chernyshev, S. D.
In: ВЕСТНИК ХИРУРГИИ ИМ. И.И. ГРЕКОВА, Vol. 185, No. 1, 20.02.2026, p. 83-90.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - ВЫРАЖЕННОСТЬ СЕПТАЛЬНОЙ РЕДУКЦИИ И ИСХОДЫ ПОСЛЕ ЭТАНОЛОВОЙ СЕПТАЛЬНОЙ АБЛАЦИИ У ПАЦИЕНТОВ С ОБСТРУКТИВНОЙ ГИПЕРТРОФИЧЕСКОЙ КАРДИОМИОПАТИЕЙ
AU - Shloydo, E. A.
AU - Kashtanov, M. G.
AU - Popov, K. V.
AU - Sergeev, A. S.
AU - Maznev, D. S.
AU - Chernyshev, S. D.
PY - 2026/2/20
Y1 - 2026/2/20
N2 - INTRODUCTION. This study examines the impact of the degree of interventricular septum reduction (<5 mm and ≥5 mm) on outcomes following alcohol septal ablation. METHODS AND MATERIALS. Data from 597 patients with obstructive hypertrophic cardiomyopathy who underwent alcohol septal ablation were analysed. Patients were divided into two groups: septal reduction <5 mm (329 patients); septal reduction ≥5 mm (268 patients). To correct the imbalance between the groups, the propensity score matching method was used. Outcomes were studied in both matched and unmatched cohorts. RESULTS. In the long-term follow-up period, 63 deaths were recorded. In the group with ≥5 mm reduction, gradients of the left ventricular outflow tract were lower (p<0.0001). Residual obstruction was more frequently observed in the <5 mm reduction group: unmatched cohort: 87 (26 %) vs. 37 (14 %), p<0.0001; matched cohort: 66 (33 %) vs. 21 (10 %), p<0.0001. Long-term survival was statistically significantly lower in the<5 mm reduction group: HR 0.47 (95 % CI: 0.24-0.89), p=0.019. CONCLUSION. Septal reduction of less than 5 mm following alcohol septal ablation is associated with: higher gradients of the left ventricular outflow tract; a higher incidence of residual obstruction; worse long-term survival.
AB - INTRODUCTION. This study examines the impact of the degree of interventricular septum reduction (<5 mm and ≥5 mm) on outcomes following alcohol septal ablation. METHODS AND MATERIALS. Data from 597 patients with obstructive hypertrophic cardiomyopathy who underwent alcohol septal ablation were analysed. Patients were divided into two groups: septal reduction <5 mm (329 patients); septal reduction ≥5 mm (268 patients). To correct the imbalance between the groups, the propensity score matching method was used. Outcomes were studied in both matched and unmatched cohorts. RESULTS. In the long-term follow-up period, 63 deaths were recorded. In the group with ≥5 mm reduction, gradients of the left ventricular outflow tract were lower (p<0.0001). Residual obstruction was more frequently observed in the <5 mm reduction group: unmatched cohort: 87 (26 %) vs. 37 (14 %), p<0.0001; matched cohort: 66 (33 %) vs. 21 (10 %), p<0.0001. Long-term survival was statistically significantly lower in the<5 mm reduction group: HR 0.47 (95 % CI: 0.24-0.89), p=0.019. CONCLUSION. Septal reduction of less than 5 mm following alcohol septal ablation is associated with: higher gradients of the left ventricular outflow tract; a higher incidence of residual obstruction; worse long-term survival.
KW - alcohol septal ablation
KW - hypertrophic cardiomyopathy
KW - left ventricular outflow tract
KW - obstruction
KW - septal reduction
UR - https://www.mendeley.com/catalogue/72682ec2-dc58-35db-973d-bb44d06b5912/
U2 - 10.24884/0042-4625-2026-185-1-83-90
DO - 10.24884/0042-4625-2026-185-1-83-90
M3 - статья
VL - 185
SP - 83
EP - 90
JO - ВЕСТНИК ХИРУРГИИ ИМ. И.И. ГРЕКОВА
JF - ВЕСТНИК ХИРУРГИИ ИМ. И.И. ГРЕКОВА
SN - 0042-4625
IS - 1
ER -
ID: 156507897