TY - JOUR

T1 - Лечебно-профилактическое действие альфа-глутамил-триптофана в отношении поражений слизистой оболочки желудка, обусловленных нестероидными противовоспалительными препаратами (экспериментальное исследование)

AU - Селина, Елена Николаевна

AU - Кудрявцева, Т.А.

AU - Гайнетдинов, Рауль Радикович

AU - Краснов, А. А.

AU - Петленко, С.В.

AU - Апрятина, Вера Анатольевна

PY - 2024

Y1 - 2024

N2 - Objective. To explore the preventive and healing impacts of orally administered alpha-glutamyl-tryptophan on gastric mucosa ulcerative lesions in rats. Material and methods. The research involved 110 male Wistar rats weighing 220±20 grams. We investigated the effects of the dipeptide alpha-glutamyl-tryptophan, administered at doses of 0.1 μg/kg and 10 μg/kg. As a comparison, we used sucralfate at a dose of 200 mg/kg. The study consisted of two sets of experiments designed to evaluate the preventative and healing effects of alpha-glutamyl-tryptophan on gastric ulcers caused by indomethacin. In addition, we analyzed the activity of superoxide dismutase (SOD) and the levels of the lipid peroxidation byproduct malondialdehyde (MDA) in the serum. Results. Preventive administration of alpha-glutamyl-tryptophan significantly mitigates the occurrence and severity of gastric ulcers, reducing ulcer frequency by up to 1.9—2.4-fold and mucosal damage by up to 2.7—3.1-fold. Additionally, there was an increase in SOD activity by up to 1.6—1.7-fold and a decrease in MDA levels, indicating reduced oxidative stress and emphasizing alpha-glutamyl-tryptophan’s antioxidant properties. Therapeutically, alpha-glutamyl-tryptophan administration post-ulcer induction led to reduction in both the number and size of gastric ulcers at a 10 μg/kg dosage—decreased by 1.5-fold and 2.7-fold, respectively, compared to indomethacin group. These results were comparable with sucralfate-treated group. Gastroprotective activity was also noted, as shown by 1.2-fold increased SOD activity and 1.5-fold decreased MDA levels. Conclusions. The findings demonstrate that alpha-glutamyl-tryptophan exhibits anti-ulcerative and antioxidant properties when administered in a prophylactic and therapeutic regimen within an indomethacin-induced model of ulceration.

AB - Objective. To explore the preventive and healing impacts of orally administered alpha-glutamyl-tryptophan on gastric mucosa ulcerative lesions in rats. Material and methods. The research involved 110 male Wistar rats weighing 220±20 grams. We investigated the effects of the dipeptide alpha-glutamyl-tryptophan, administered at doses of 0.1 μg/kg and 10 μg/kg. As a comparison, we used sucralfate at a dose of 200 mg/kg. The study consisted of two sets of experiments designed to evaluate the preventative and healing effects of alpha-glutamyl-tryptophan on gastric ulcers caused by indomethacin. In addition, we analyzed the activity of superoxide dismutase (SOD) and the levels of the lipid peroxidation byproduct malondialdehyde (MDA) in the serum. Results. Preventive administration of alpha-glutamyl-tryptophan significantly mitigates the occurrence and severity of gastric ulcers, reducing ulcer frequency by up to 1.9—2.4-fold and mucosal damage by up to 2.7—3.1-fold. Additionally, there was an increase in SOD activity by up to 1.6—1.7-fold and a decrease in MDA levels, indicating reduced oxidative stress and emphasizing alpha-glutamyl-tryptophan’s antioxidant properties. Therapeutically, alpha-glutamyl-tryptophan administration post-ulcer induction led to reduction in both the number and size of gastric ulcers at a 10 μg/kg dosage—decreased by 1.5-fold and 2.7-fold, respectively, compared to indomethacin group. These results were comparable with sucralfate-treated group. Gastroprotective activity was also noted, as shown by 1.2-fold increased SOD activity and 1.5-fold decreased MDA levels. Conclusions. The findings demonstrate that alpha-glutamyl-tryptophan exhibits anti-ulcerative and antioxidant properties when administered in a prophylactic and therapeutic regimen within an indomethacin-induced model of ulceration.

KW - alpha-glutamyl-tryptophan

KW - antioxidant properties

KW - gastric ulcers

KW - non-steroidal anti-inflammatory drugs gastropathy

KW - oxidative stress

UR - https://www.mendeley.com/catalogue/b950574e-6628-36cc-b24d-d32384137473/

U2 - 10.17116/dokgastro20241302125

DO - 10.17116/dokgastro20241302125

M3 - статья

VL - 13

SP - 25

EP - 34

JO - Доказательная гастроэнтерология

JF - Доказательная гастроэнтерология

SN - 2305-2260

IS - 2

ER -