This research presents an interpretation of reception of philosophy of G. Deleuze and F. Guattari in architectural theory of Japanese architects in the 80-s. The aim of the article is comparative and hermeneutic analysis of spatial constants in Japanese and European cultures. Such concepts as rhizome, machine, lines of flight, chaosmos were very popular for Japanese architects in 1980-s. Ideas of metabolism and symbiosis of Japanese architect Kisho Kurokawa, projects and interviews between S. Takamatsu and F. Guattari are used to compare classical European spatial paradigm, Japanese tradition and its transformation in XX century. Interaction of Japanese architects with French thinkers opened up the possibility of dialogue not only between different cultures but also between different types of describing the space: architectural and philosophical. The article considers problems of variability and heterogeneity in architectural buildings; the possibility of its interaction with cultural landscape; a rejection of universal topological model. In this regard the concepts of desubjectivation and autonomization of space deserve special attention in dialogues of F. Guattari and S. Takamatsu. This problem in projects of 80-s concerns the status of modern architecture in it’s algorithmic, digital and nonhuman dimension in XXI century.