Historical data on the development of the gout doctrine and the role of E. S. London in the development of this problem are given. Purine metabolism was studied in 279 patients with autoimmune Hashimoto's thyroiditis complicated by hypothyrosis, the role of age and overweight in the formation of hyperuricemia and its positive dynamics in the treatment of thyroid hormone and allopurinol was shown. The obtained data may testify in favor of the bilateral relations between the development of autoimmune damage of setuid-tion of cancer and hyperuricemia (14 figs, 4 tables, bibliography: 46 refs).