TY - JOUR

T1 - Изменение уровня С-реактивного белка в зависимости от тяжести течения локализованного пародонтита травматической этиологии

AU - Smirnova, A.V.

AU - Kuzmina, D.A.

AU - Semiglazova, Y.F.

AU - Iordanishvili, A.K.

N1 - Export Date: 11 March 2024 Адрес для корреспонденции: Smirnova, A.V.; North-Western State Medical University named after I.I. MechnikovRussian Federation; эл. почта: sandra.08.03@mail.ru Пристатейные ссылки: Machado, V, Botelho, J, Escalda, C, Hussain, SB, Luthra, S, Mascarenhas, P, Orlandi, M, D´Aiuto, F., Serum C-reactive protein and periodontitis: A systematic review and meta-analysis (2021) Front Immunol, 12, p. 706432; Vel'kov, VV., Predictors: Heart attacks and strokes can be prevented if their risk is assessed in time (2008) Dalnevostochnyy meditsinskiy zhurnal, (3), pp. 122-126. , Вельков В.В. Предикторы: инфаркты и инсульты можно предотвратить, если вовремя оценить их риск. Дальневосточный медицинский журнал. 2008;(3):122–126. [(In Russ)] EDN: JKLASL; Yudina, NA., The relationship between periodontal diseases and somatic pathology (2022) Sovremennaya stomatologiya, (1), pp. 2-6. , Юдина Н.А. Взаимосвязь заболеваний периодонта и соматической патологии. Современная стоматология. 2022;(1):2–6. [(In Russ)] EDN: CTGNDU; Tanke, HJ., Genomics and proteomics: The potential role of oral diagnostics (2007) Ann N Y Acad Sci, 1098, pp. 330-334; Pejcic, A, Kesic, LJ, Milasin, J., C-reactive protin as a systemic marker of inflammation in periodontitis (2011) Eur J Clin Microbiol Infect Dis, 30 (3), pp. 407-414; Luthra, S, Orlandi, M, Hussain, SB, Leira, Y, Botelho, J, Machado, V, Mendes, JJ, D´Aiuto, F., Treatment of periodontitis and C-reactive protein: A systematic review and meta-analysis of randomized clinical trials (2023) J Clin Periodontol, 50 (1), pp. 45-60; Ebersole, JL, Graves, CL, Gonzalez, OA, Morford, LA, Huja, PE, Hartsfield, JK, Huja, SS, Wallet, SM., Aging, inflammation, immunity and periodontal disease (2016) Periodontol 2000, 72 (1), pp. 54-75. , Dawson 3rd D; Gazhva, SI, Guluev, RS., Prevalence and intensity of inflammatory periodontal diseases (literature review) (2012) Obozrenie. Medtekhnika. Stomatologiya, 1 (75), pp. 13-14. , Гажва С.И., Гулуев Р.С. Распространённость и интенсивность воспалительных заболеваний пародонта (обзор литературы). Обозрение. Медтехника. Стоматология. 2012;1(75):13–14. [(In Russ)]; Tamarova, ER, Mavzutov, AR., Study of the prevalence of somatic pathology among patients with periodontitis (2013) Chelovek i ego zdorove, 3, pp. 53-56. , Тамарова Э.Р., Мавзютов А.Р. Исследование распространённости соматической патологии у больных пародонтитом. Человек и его здоровье. 2013;3:53–56. [(In Russ)] EDN: RURHBR; Miklyaev, SV, Leonova, OM, Sushchenko, AV., Analysis of the prevalence of chronic inflammatory diseases of periodontal tissues (2018) Modern problems of science and education, (2), p. 15. , Микляев С.В., Леонова О.М., Сущенко А.В. Анализ распространённости хронических воспалительных заболеваний тканей пародонта. Современные проблемы науки и образования. 2018;(2):15. [(In Russ)] EDN: XNYEHR; Grudyanov, AI, Tkacheva, ON, Avraamova, TV, Khvatova, NT., The relationship between inflammatory periodontal diseases and cardiovascular diseases (2015) Stomatologiya, 94 (3), pp. 50-55. , Грудянов А.И., Ткачева О.Н., Авраамова Т.В., Хватова Н.Т. Вопросы взаимосвязи воспалительных заболеваний пародонта и сердечно-сосудистой патологии. Стоматология. 2015;94(3):50–55. [(In Russ)]; Hedge, R, Awan, KH., Effects of periodontal disease on systemic health (2019) Dis Mon, 65 (6), pp. 185-192; Gupta, S, Suri, P, Patil, P, Rajguru, JP, Gupta, P, Patel, N., Comparative evaluation of role of hs C-reactive protein as a diagnostic marker in chronic periodontitis patients (2020) J Family Med Prim Care, 9 (3), pp. 1340-1347; Singer, RE, Moss, K, Kim, SJ, Beck, JD, Offenbacher, S., Oxidative stress and IgG antibody modify periodontitis-CRP association (2015) J Dent Res, 94 (12), pp. 1698-1705; Schöffer, C, Oliveira, LM, Santi, SS, Antoniazzi, RP, Zanatta, FB., C-reactive protein levels are associated with periodontitis and periodontal inflamed surface area in adults with end-stage renal disease (2021) J Periodontol, 92 (6), pp. 793-802; Karattil, LV, Joseph, RS, Ambooken, M, Mathew, JJ., Evaluation of serum concentrations of HS-CRP and HB in varying severities of chronic periodontitis (2022) Biomarkers, 27 (3), pp. 258-263; Tuominen, H, Taina, M, Puranen, M, Onatsu, J, Huumonen, S, Vanninen, R., Serum high-sensitive C-reactive protein may reflect periodontitis in patients with stroke (2020) Vivo, 34 (5), pp. 2829-2835; Sezgin, Y, Bulut, Ş, Bozalioğlu, S, Sezgin, A., Levels of high-sensitivity C-reactive protein in heart transplant patients with and without periodontitis (2019) Exp Clin Transplant, 17 (1), pp. 123-127; Orlandi, M, Aguilera, EM, Marletta, D, Petrie, A, Suvan, J, D´Aiuto, F., Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review (2022) J Clin Periodontol, 49 (24), pp. 314-327; Kakabadze, AI, Semiglazova, YuF, Smirnova, AV, Kuzmina, DA., The role of somatic diseases in aggravated course of localized periodontitis of traumatic etiology (2022) Meditsinskiy alyans, 10 (2), pp. 84-90. , Какабадзе А.И., Семиглазова Ю.Ф., Смирнова А.В., Кузьмина Д.А. Роль соматической патологии в отягощении течения локализованного пародонтита травматической этиологии. Медицинский альянс. 2022;10(2):84–90. [(In Russ)]

PY - 2024/2/2

Y1 - 2024/2/2

N2 - Background. The significant prevalence and course of inflammatory periodontal diseases are associated not only with the presence of known bacterial agents, but also with changes in the body’s immune system that occur as a result of aging. Aim. To establish the relationship between the level of C-reactive protein in the blood and the course of localized periodontitis of traumatic etiology. Material and methods. During 2016–2019 169 patients with localized periodontitis of traumatic etiology (average age 56.44±0.14 years) of mild (102 people) and moderate (67 patients) severity at the Department of General Practice Dentistry of the North-Western State Medical University named after I.I. Mechnikov were examined. An in-depth dental examination, determination of periodontal indices, assessment of laboratory parameters (determination of high-sensitivity C-reactive protein, assessment and calculation of the entropy of the blood leukocyte formula), complex treatment using splinting with orthopedic structures in the main group (69 patients) and without it in the comparison group (57 people) were carried out. Statistical processing of data was conducted using the Shapiro–Wilk, Pearson, Kolmogorov–Smirnov tests, Fisher’s exact test and χ2 test, and calculation of relative risk. Results. Oral hygiene was good (hygiene index 0.54±0.18) and satisfactory (hygiene index 0.79±0.21) with mild and moderate severity, respectively. The local Mulleman–Cowell index was increased by 2.7 times (1.43±0.50) with mild severity and almost 4 times (2.31±0.33) with moderate severity of localized periodontitis of traumatic etiology compared with general index (0.52±0.12; 0.64±0.18). In localized periodontitis of traumatic etiology of moderate severity, an increase in the number of monocytes (8.7±2.12×109/l) and band neutrophils (5.4±1.47×109/l), an increase in the relative entropy of the leukocyte blood count (72.3±21.12%) compared with mild severity (62.8±14.9%; p=0.00089) were identified. With C-reactive protein concentrations ranging from 3 to 10 mg/l, the risk of developing localized periodontitis of moderate traumatic etiology increased by 1.74 times compared with C-reactive protein levels of less than 3 mg/l (p=0.0022). Conclusion. In localized periodontitis of moderate traumatic etiology, an increase in the number of band neutrophils and monocytes, as well as the relative entropy of the leukocyte blood count was detected. Preclinical increases in the concentration of C-reactive protein contribute to an increase in the severity of the disease. © Eco-Vector, 2023. All rights reserved.

AB - Background. The significant prevalence and course of inflammatory periodontal diseases are associated not only with the presence of known bacterial agents, but also with changes in the body’s immune system that occur as a result of aging. Aim. To establish the relationship between the level of C-reactive protein in the blood and the course of localized periodontitis of traumatic etiology. Material and methods. During 2016–2019 169 patients with localized periodontitis of traumatic etiology (average age 56.44±0.14 years) of mild (102 people) and moderate (67 patients) severity at the Department of General Practice Dentistry of the North-Western State Medical University named after I.I. Mechnikov were examined. An in-depth dental examination, determination of periodontal indices, assessment of laboratory parameters (determination of high-sensitivity C-reactive protein, assessment and calculation of the entropy of the blood leukocyte formula), complex treatment using splinting with orthopedic structures in the main group (69 patients) and without it in the comparison group (57 people) were carried out. Statistical processing of data was conducted using the Shapiro–Wilk, Pearson, Kolmogorov–Smirnov tests, Fisher’s exact test and χ2 test, and calculation of relative risk. Results. Oral hygiene was good (hygiene index 0.54±0.18) and satisfactory (hygiene index 0.79±0.21) with mild and moderate severity, respectively. The local Mulleman–Cowell index was increased by 2.7 times (1.43±0.50) with mild severity and almost 4 times (2.31±0.33) with moderate severity of localized periodontitis of traumatic etiology compared with general index (0.52±0.12; 0.64±0.18). In localized periodontitis of traumatic etiology of moderate severity, an increase in the number of monocytes (8.7±2.12×109/l) and band neutrophils (5.4±1.47×109/l), an increase in the relative entropy of the leukocyte blood count (72.3±21.12%) compared with mild severity (62.8±14.9%; p=0.00089) were identified. With C-reactive protein concentrations ranging from 3 to 10 mg/l, the risk of developing localized periodontitis of moderate traumatic etiology increased by 1.74 times compared with C-reactive protein levels of less than 3 mg/l (p=0.0022). Conclusion. In localized periodontitis of moderate traumatic etiology, an increase in the number of band neutrophils and monocytes, as well as the relative entropy of the leukocyte blood count was detected. Preclinical increases in the concentration of C-reactive protein contribute to an increase in the severity of the disease. © Eco-Vector, 2023. All rights reserved.

KW - C-reactive protein, localized periodontitis of traumatic etiology

UR - https://www.mendeley.com/catalogue/1f99d453-073d-3abf-9665-7786fbffb0e0/

U2 - 10.17816/kmj569217

DO - 10.17816/kmj569217

M3 - статья

VL - 105

SP - 26

EP - 32

JO - Kazan Medical Journal

JF - Kazan Medical Journal

SN - 0368-4814

IS - 1

ER -