Introduction. Road traffic accidents (RTA) in the war zone represent a special problem associated with the delay of evacuation and the impossibility of rapid delivery to a trauma center of the appropriate level. In the conditions of pre-hospital care, when time plays a decisive role and bleeding is a direct threat to life, timely transfusion can improve outcomes. The objective was to demonstrate the possibility of performing blood transfusion in conditions of a forcedly extended pre-hospital stage. Clinical case. The victim was trapped in a car. First aid was provided at the accident scene. After being removed from the car, the victim was transported to a full-fledged evacuation stage, where the victim received advanced first aid (with elements of qualified care): transfusion of whole blood and blood components, and stabilization of pelvic and long-bone fractures. Results. Timely replacement of blood loss has a positive impact on the prognosis of patients with acute massive bleeding. Whole blood is the most effective means of stopping bleeding due to its complex hemostatic effect. Therefore, the early use of preserved whole blood of universal group appears to be a promising tool for correcting blood loss. Conclusion. The use of whole blood of a universal group O(I) Rh(–) as a primary resuscitative agent is justified by its availability and balanced composition. Combined with early surgical damage control, this strategy may improve survival in cases of severe trauma.