TY - JOUR

T1 - Анализ факторов риска и структуры перинатальных потерь у беременных с сахарным диабетом

AU - Капустин, Роман Викторович

AU - Коптеева, Екатерина Вадимовна

AU - Алексеенкова, Елена Николаевна

AU - Цыбук, Елизавета Михайловна

AU - Аржанова, Ольга Николаевна

PY - 2021

Y1 - 2021

N2 - Study Objective: To analyse risk factors and perinatal mortality structure in patients with various types of diabetes mellitus (DM) over the last 30 years in specialised settings. Study Design: retrospective single-site cohort study. Materials and Methods. We have studied 42 medical records containing cases of perinatal death of foetus or newborn in 1988–2018 in patients with DM1 (n = 20), DM2 (n = 10), gestational DM (n = 12). Study Results. The most common complication in pregnancy was preeclampsia combined with chronic placental insufficiency (47.6%). The most common risk factors of perinatal death were inadequate glycemic control in 1st trimester (69.0%), absence of preconception preparations (66.7%), preconception overweight and obesity (42.8%), and chronic arterial hypertension (28.6%). There were 38.1% antenatal deaths, 16.7% intranatal deaths, and 45.2% cases of postnatal mortality. The major causes of perinatal foetal mortality in 26.2% cases were placental disorders, 16.7% were associated with foetus growth retardation, diabetic fetopathy and respiratory distress syndrome. Conclusion. DM during pregnancy was associated with a higher risk of perinatal death. Timely preconception preparation, BMI normalization and a consolidated approach to term and mode of delivery can reduce the risk of perinatal mortality in women with various types of DM. Keywords: diabetes mellitus, gestational diabetes mellitus, perinatal mortality, stillbirth, obesity, preeclampsia

AB - Study Objective: To analyse risk factors and perinatal mortality structure in patients with various types of diabetes mellitus (DM) over the last 30 years in specialised settings. Study Design: retrospective single-site cohort study. Materials and Methods. We have studied 42 medical records containing cases of perinatal death of foetus or newborn in 1988–2018 in patients with DM1 (n = 20), DM2 (n = 10), gestational DM (n = 12). Study Results. The most common complication in pregnancy was preeclampsia combined with chronic placental insufficiency (47.6%). The most common risk factors of perinatal death were inadequate glycemic control in 1st trimester (69.0%), absence of preconception preparations (66.7%), preconception overweight and obesity (42.8%), and chronic arterial hypertension (28.6%). There were 38.1% antenatal deaths, 16.7% intranatal deaths, and 45.2% cases of postnatal mortality. The major causes of perinatal foetal mortality in 26.2% cases were placental disorders, 16.7% were associated with foetus growth retardation, diabetic fetopathy and respiratory distress syndrome. Conclusion. DM during pregnancy was associated with a higher risk of perinatal death. Timely preconception preparation, BMI normalization and a consolidated approach to term and mode of delivery can reduce the risk of perinatal mortality in women with various types of DM. Keywords: diabetes mellitus, gestational diabetes mellitus, perinatal mortality, stillbirth, obesity, preeclampsia

KW - САХАРНЫЙ ДИАБЕТ, ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ, ПЕРИНАТАЛЬНАЯ СМЕРТНОСТЬ, МЕРТВОРОЖДЕНИЕ, ОЖИРЕНИЕ, ПРЕЭКЛАМПСИЯ

UR - https://www.mendeley.com/catalogue/9d771752-9919-3629-b4e6-21ea4e31e11e/

U2 - 10.31550/1727-2378-2021-20-6-46-52

DO - 10.31550/1727-2378-2021-20-6-46-52

M3 - статья

VL - 20

SP - 46

EP - 52

JO - ДОКТОР.РУ

JF - ДОКТОР.РУ

SN - 1727-2378

IS - 6

ER -