The objective. Development of a highly sensitive method of screening for protein-energy malnutrition (PEM) in patients who receive treatment by automated haemodialysis (HD). Patients and methods. The examination included 645 patients who received automated dialysis for 8.4 ± 5.3 years, among them 345 women and 300 men, the mean age was 56.8 ± 12.8 years. Their nutritional status was assessed for diagnosis of PEM using the method of the Ministry of Health of Russia (MHR) and a method proposed by the International Society of Renal Nutrition and Metabolism (ISRNM). For PEM screening, the Malnutrition Universal Screening Tool (MUST), Nutritional Risk Screening (NRS), Nottingham screening tool (NST), Malnutrition Screening Tool (MST), Malnutrition-Inflammation Score (MIS) were used. Results. According to ROC analysis findings, MIS has demonstrated the highest predictive value in screening for PEM in haemodialysis patients, but the area under the ROC curve (AUC) did not exceed 0.57, which is indicative of a low efficacy of the examined methods for PEM screening. The results of ROC analysis of the «MEGASKRIN» test developed for PEM screening in haemodialysis patients have shown the area under the ROC curve (AUC) to 0.92 (95% Confidence interval was 0.88-0.96). Conclusion. The use of the «MEGASKRIN» method for PEM screening in haemodialysis patients have demonstrated an acceptable predictive value and might be recommended for routine use in screening for PEM in this cohort of patients irrespective of a subsequent method for PEM diagnosis.