РОЛЬ ЯДЕРНЫХ ЛАМИНОВ А/С В ОСТЕОГЕННОЙ ДИФФЕРЕНЦИРОВКЕ МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТРОМАЛЬНЫХ КЛЕТОК. / Богданова, М.А.; Гудкова, А.Я.; Забирник, А.С.; Игнатьева, Е.В.; Дмитриева, Р.И.; Смолина, Н.А.; Костарева, А.А.; Малашичева, А.Б.
In: Цитология, Vol. 56, No. 4, 2014, p. 260-267.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - РОЛЬ ЯДЕРНЫХ ЛАМИНОВ А/С В ОСТЕОГЕННОЙ ДИФФЕРЕНЦИРОВКЕ МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТРОМАЛЬНЫХ КЛЕТОК
AU - Богданова, М.А.
AU - Гудкова, А.Я.
AU - Забирник, А.С.
AU - Игнатьева, Е.В.
AU - Дмитриева, Р.И.
AU - Смолина, Н.А.
AU - Костарева, А.А.
AU - Малашичева, А.Б.
PY - 2014
Y1 - 2014
N2 - Nuclear lamins are the major proteins of nuclear envelope and provide the strength of nuclear membrane as well as the interaction of extra-nuclear structures with components of cell nucleus. Recently, it became clear that lamins not only play a structural role in the cell, but could also regulate cell fate, for example lamins could influence cell differentiation via interaction with components of the Notch signaling pathway. Human mutations in LMNA, encoding lamin A/C lead to diseases commonly referred to as laminopathies. Different mutations cause tissue specific phenotypes that affect predominantly a tissue of mesenchymal origin. The nature of this phenomenon, as well as the mechanisms by which lamins regulate cell differentiation remain poorly understood. The aim of this study was to investigate the effect of different mutations of the LMNA on human mesenchymal stem cell (MSC) osteogenic differentiation, and to explore a possible interaction of lamins and Notch signaling pathway. We modified human MSC with
AB - Nuclear lamins are the major proteins of nuclear envelope and provide the strength of nuclear membrane as well as the interaction of extra-nuclear structures with components of cell nucleus. Recently, it became clear that lamins not only play a structural role in the cell, but could also regulate cell fate, for example lamins could influence cell differentiation via interaction with components of the Notch signaling pathway. Human mutations in LMNA, encoding lamin A/C lead to diseases commonly referred to as laminopathies. Different mutations cause tissue specific phenotypes that affect predominantly a tissue of mesenchymal origin. The nature of this phenomenon, as well as the mechanisms by which lamins regulate cell differentiation remain poorly understood. The aim of this study was to investigate the effect of different mutations of the LMNA on human mesenchymal stem cell (MSC) osteogenic differentiation, and to explore a possible interaction of lamins and Notch signaling pathway. We modified human MSC with
M3 - статья
VL - 56
SP - 260
EP - 267
JO - Цитология
JF - Цитология
SN - 0041-3771
IS - 4
ER -
ID: 7064590