Research output: Contribution to journal › Article › peer-review
ПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ОБРАЗОВАНИЯ АУТОАНТИТЕЛ К СТРУКТУРАМ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ ПРИ ЭНЦЕФАЛИТАХ. / Скрипченко, Наталья Викторовна; Скрипченко, Е. Ю.; Жданов, Константин Валерьевич; Алексеева, Лидия Аркадьевна; Вербенко, Полина Сергеевна; Суслопарова, П.С.
In: ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА, Vol. 125, No. 4, 12.05.2025, p. 53-58.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - ПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ОБРАЗОВАНИЯ АУТОАНТИТЕЛ К СТРУКТУРАМ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ ПРИ ЭНЦЕФАЛИТАХ
AU - Скрипченко, Наталья Викторовна
AU - Скрипченко, Е. Ю.
AU - Жданов, Константин Валерьевич
AU - Алексеева, Лидия Аркадьевна
AU - Вербенко, Полина Сергеевна
AU - Суслопарова, П.С.
PY - 2025/5/12
Y1 - 2025/5/12
N2 - In this article we review the world literature on the influence of infectious agents on the development of autoimmune encephalitis in children and adults, as well as modern ideas about the transformation of infectious encephalitis into autoimmune one. The information is presented about the main links of pathogenesis reflecting the dysfunction of the immune system, which may explain the formation of autoantibodies and the beginning of autoimmune mechanisms of damage to the structures of the central nervous system. The characteristics of laboratory parameters that can be used as prognostic markers to determine the severity of the course of infectious encephalitis and the probability of their transformation into autoimmune encephalitis are given. Proposals are presented on the tactics of etiotropic therapy in patients with suspected infectious encephalitis using the drug meglumine acridone acetate-cycloferon, which has antiviral, immunomodulatory and anti-inflammatory effects.
AB - In this article we review the world literature on the influence of infectious agents on the development of autoimmune encephalitis in children and adults, as well as modern ideas about the transformation of infectious encephalitis into autoimmune one. The information is presented about the main links of pathogenesis reflecting the dysfunction of the immune system, which may explain the formation of autoantibodies and the beginning of autoimmune mechanisms of damage to the structures of the central nervous system. The characteristics of laboratory parameters that can be used as prognostic markers to determine the severity of the course of infectious encephalitis and the probability of their transformation into autoimmune encephalitis are given. Proposals are presented on the tactics of etiotropic therapy in patients with suspected infectious encephalitis using the drug meglumine acridone acetate-cycloferon, which has antiviral, immunomodulatory and anti-inflammatory effects.
KW - autoantibodies
KW - autoimmune encephalitis
KW - children
KW - infectious encephalitis
KW - meglumine acridone acetate-Cycloferon
KW - post-infectious encephalitis
KW - prognosis
UR - https://www.mendeley.com/catalogue/3ba453cb-48ef-3643-9024-b3ab904fa4ec/
U2 - 10.17116/jnevro202512504153
DO - 10.17116/jnevro202512504153
M3 - статья
VL - 125
SP - 53
EP - 58
JO - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА
JF - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА
SN - 1997-7298
IS - 4
ER -
ID: 139654919