OBJECTIVE. The reason of therapeutic and diagnostic tactics in patients with otogenic venous sinus thrombosis of the brain.MATERIAL AND METHOD. The analysis of 89 clinical cases of treatment of patients with meningoencephalitis due to inflammatory diseases of the middle ear.RESULTS. The differentiated tactics was used during the surgical treatment of patients with intracranial purulent inflammatory diseases differentiated tactics. This tactics depended on the results of CT or MRI studies of the brain, the clinical stage of an intracerebral abscess and the organ dysfunction of the patient.CONCLUSION. At the primary medical care stage it is necessary to identify predictors of infectious brain damage. If they are identified, the patient evacuation to a hospital is recommended urgently. CT of the temporal bones CT and MRI of the brain are performed in a hospital. A surgical sanation of infection sites, a systemic, regional antibiotic therapy are began to perform.