The article presents data on the study of the relationship between psychological and psycho-physiological characteristics in the experience of daily stressors. Participants were 326 adults aged 20 to 68 years (male n=117, female n=209). Confirmatory factor analysis revealed a direct effect on the reduction of daily stressors situations such characteristics as emotional stability and hyperthymia/self-confidence; the impact of the high level of daily hassles in raising "the age of the vessels", "heart rate", " rigidity of vessels " and such psychological characteristics as frustration and impulsiveness. Discovered that the internality acts as the moderator, and the stability of the neural response contributes to increase internality and reduce anxiety and tension.