Background. Development of effective methods of personalized drug therapy and psychotherapy of nonpsychotic mental disorders is an important area of modern psychiatric practice aimed at ensuring optimal health and psychological well-being of patients. Objective: to determine the principles of diagnosis, treatment and stabilization of remission in patients with comorbid depressive and anxiety disorders of the neurotic spectrum based on an individualized approach. Results and Discussion. The article considers a clinical case of a patient with symptoms of depression and anxiety of psychogenic origin, indicative of diagnosis, treatment and stabilization of remission in patients with comorbid depressive and anxiety disorders of the neurotic spectrum. The process of establishing an accurate diagnosis, ways of choosing the tactics of pharmacological management of the patient, justification for choosing an effective method of psychotherapy are demonstrated. Using the example of a single case history and anamnestic data on the formation and development of psychopathological symptoms, the psychological mechanisms underlying the manifestation and maintenance of neurotic symptoms that prevent the stabilization of remission are analyzed. The process of personally oriented (reconstructive) psychotherapy is shown, short-term and long-term treatment results are presented. This case description was prepared in accordance with the CARE recommendations. © 2025, Mental Health Research Institute. All rights reserved.