The etiology of plantar warts in both children and adults is primarily linked to human papillomavirus (HPV) infection. Patients frequently report issues such as discomfort, trauma to the affected areas, and recurrent lesions following wart removal. Current treatment approaches emphasize the importance of combining physical destruction of warts with the use of non-specific antiviral and immunomodulatory therapies. We present the case of a 13-year-old male patient diagnosed with multiple plantar warts that were non-responsive to topical sodium hydroxide therapy. Additionally, new lesions continued to develop despite prior immunotherapy interventions. The patient was prescribed an oral combination therapy containing sodium alpha-glutamyl-tryptophan (0.5 mg), administered three times daily in two 4-day courses with a 10-day interval between courses. Concurrently, a topical cream containing sodium alpha-glutamyl-tryptophan (0.05%) was applied to the affected skin areas 2–3 times daily for two weeks. By the end of the two-week topical treatment, significant healing within the deeper layers of the epidermis was observed. Complete resolution of the warts occurred within four weeks, with no recurrence observed during a three-month follow-up period. This case highlights that a combination therapy approach — oral administration of an immunomodulatory preparation containing alpha-glutamyl-tryptophan, ascorbic acid, and bendazole, alongside daily topical application of 0.05% alpha-glutamyl-tryptophan cream — proved to be effective and well-tolerated for treating multiple plantar warts in a pediatric patient. The prescribed regimen not only facilitated complete lesion resolution but also successfully prevented recurrences, markedly improving the patient's quality of life. © 2025 Meditsina-Inform LLC. All rights reserved.