Purpose - to assess the impact of pseudoexfoliation syndrome (PEX) on the accuracy of intraocular lens (IOL) power calculation. Material and methods. The study included 243 patients who underwent phacoemulsification (PE); they were divided into the control (no PEX signs, n=131) and study (signs of PEX, n=112) groups. Barrett Universal II formula was used for IOL calculation by optical biometry (IOL-Master 500). Obtained refraction (autorefractometer Topcon-8800) was compared with target refraction to assess IOL calculation accuracy 1 month after PE. Results. Patients with PEX had significantly shallower anterior chamber compared to the control group (2.86±0.43 versus 3.0±0.43 mm, p=0.003) and steeper corneal curvature (44.31±1.5 versus 43.7±2.59 D, p=0.052). There was significant difference in absolute error of IOL calculation between the groups (-0.02±0.45 versus 0.17±0.55 D for control and study groups, respectively, p=0.004). There was no difference in IOL calculation error depending on the implanted IOL models (AcrySof SA60AT and Akreos Adapt AO) in the control group. However, implantation of SA60AT in the study group showed significant difference in IOL calculation error compared with Akreos (0.3±0.57 versus 0.04±0.51 D, p=0.01). Using linear regression, optimized A-constants were suggested for these types of IOLs for patients with PEX (118.83 for SA60AT and 118.44 for Akreos).