The study was aimed at studying the subjective perception of interpersonal interaction by patients with psoriasis (66 people). Comparison of patients of this nosological group with groups of patients with cardiovascular diseases and pathology of the musculoskeletal system, carried out using statistical and psychological methods, showed a pronounced specificity of patients with psoriasis. It was found that these patients are characterized by anxiety about their own attractiveness, a tendency to depressed mood and submission in the process of interpersonal interaction.