Research output: Contribution to journal › Article › peer-review
Нарушения сна при болезни Альцгеймера. / Колмакова, Кристина Андреевна; Лобзин, Владимир Юрьевич; Емелин, Андрей Юрьевич.
In: ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА, Vol. 124, No. 4-2, 29.04.2026, p. 56-62.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Нарушения сна при болезни Альцгеймера
AU - Колмакова, Кристина Андреевна
AU - Лобзин, Владимир Юрьевич
AU - Емелин, Андрей Юрьевич
N1 - Колмакова К.А., Лобзин В.Ю., Емелин А.Ю. Нарушения сна при болезни Альцгейме-ра. Журнал неврологии и психиатрии им. С.С. Корсакова. 2026;124(4 2):56 62.
PY - 2026/4/29
Y1 - 2026/4/29
N2 - This article investigates the progression of sleep disturbances in Alzheimer's disease (AD) and the mechanisms by which these disturbances may accelerate neurodegeneration. Key electrophysiological patterns identified through polysomnography in patients with AD and sleep disorders are analyzed. Therapeutic interventions are reviewed, with non-pharmacological and pharmacological approaches considered separately. The roles of cognitive behavioural therapy, relaxation techniques, and optimization of sleep conditions are emphasized. Current pharmacological treatment options are discussed, highlighting the need for careful drug selection due to the high risk of adverse effects and the potential dangers of certain medications, such as benzodiazepines and cyclopyrroles, in elderly patients with cognitive impairment. The use of memantine as a foundational therapy is given particular attention, as it may improve both cognitive function and sleep quality.
AB - This article investigates the progression of sleep disturbances in Alzheimer's disease (AD) and the mechanisms by which these disturbances may accelerate neurodegeneration. Key electrophysiological patterns identified through polysomnography in patients with AD and sleep disorders are analyzed. Therapeutic interventions are reviewed, with non-pharmacological and pharmacological approaches considered separately. The roles of cognitive behavioural therapy, relaxation techniques, and optimization of sleep conditions are emphasized. Current pharmacological treatment options are discussed, highlighting the need for careful drug selection due to the high risk of adverse effects and the potential dangers of certain medications, such as benzodiazepines and cyclopyrroles, in elderly patients with cognitive impairment. The use of memantine as a foundational therapy is given particular attention, as it may improve both cognitive function and sleep quality.
KW - Alzheimer’s disease
KW - insomnia
KW - light therapy
KW - lymphatic system
KW - memantine
KW - polysomnography
KW - sleep disorders
KW - slow-wave sleep
KW - β-amyloid
UR - https://www.mendeley.com/catalogue/8ca8791e-15f6-3dc4-8a07-44a8039e6a62/
U2 - 10.17116/jnevro202612604256
DO - 10.17116/jnevro202612604256
M3 - статья
VL - 124
SP - 56
EP - 62
JO - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА
JF - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА
SN - 1997-7298
IS - 4-2
ER -
ID: 153033239