This article investigates the progression of sleep disturbances in Alzheimer's disease (AD) and the mechanisms by which these disturbances may accelerate neurodegeneration. Key electrophysiological patterns identified through polysomnography in patients with AD and sleep disorders are analyzed. Therapeutic interventions are reviewed, with non-pharmacological and pharmacological approaches considered separately. The roles of cognitive behavioural therapy, relaxation techniques, and optimization of sleep conditions are emphasized. Current pharmacological treatment options are discussed, highlighting the need for careful drug selection due to the high risk of adverse effects and the potential dangers of certain medications, such as benzodiazepines and cyclopyrroles, in elderly patients with cognitive impairment. The use of memantine as a foundational therapy is given particular attention, as it may improve both cognitive function and sleep quality.
Translated title of the contributionSleep disorders in Alzheimer’s disease
Original languageRussian
Pages (from-to)56-62
Number of pages7
JournalЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА
Volume124
Issue number4-2
DOIs
StatePublished - 29 Apr 2026

    Research areas

  • Alzheimer’s disease, insomnia, light therapy, lymphatic system, memantine, polysomnography, sleep disorders, slow-wave sleep, β-amyloid

ID: 153033239