КОМБИНИРОВАННАЯ ГЕПАТОПРОТЕКТОРНАЯ ФАРМАКОТЕРАПИЯ ЗАБОЛЕВАНИЙ ПЕЧЕНИ. / Оковитый, Сергей Владимирович; Райхельсон, Карина Леонидовна; Приходько, Вероника Александровна.
In: Экспериментальная и клиническая гастроэнтерология, Vol. 203, No. 7, 07.10.2022, p. 5-20.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - КОМБИНИРОВАННАЯ ГЕПАТОПРОТЕКТОРНАЯ ФАРМАКОТЕРАПИЯ ЗАБОЛЕВАНИЙ ПЕЧЕНИ
AU - Оковитый, Сергей Владимирович
AU - Райхельсон, Карина Леонидовна
AU - Приходько, Вероника Александровна
PY - 2022/10/7
Y1 - 2022/10/7
N2 - Fixed-dose drug products as well as non-fixed hepatoprotective drug combinations are commonly used in modern clinical practice. Combined and concurrent drug use makes it possible to augment the pharmacological effects of individual agents, or extend the range of their potential indications. The drugs most commonly considered for combination therapy include essential phospholipids, glycyrrhizinic acid, ursodeoxycholic acid, silibinin, and S-adenosylmethionine. This paper discusses the rationale for combined use of liver-targeting drugs from a pathogenetic viewpoint, and provides a review of the evidence from clinical trials on combined pharmacotherapy for liver disease.
AB - Fixed-dose drug products as well as non-fixed hepatoprotective drug combinations are commonly used in modern clinical practice. Combined and concurrent drug use makes it possible to augment the pharmacological effects of individual agents, or extend the range of their potential indications. The drugs most commonly considered for combination therapy include essential phospholipids, glycyrrhizinic acid, ursodeoxycholic acid, silibinin, and S-adenosylmethionine. This paper discusses the rationale for combined use of liver-targeting drugs from a pathogenetic viewpoint, and provides a review of the evidence from clinical trials on combined pharmacotherapy for liver disease.
KW - S-adenosylmethionine
KW - essential phospholipids
KW - glycyrrhizinic acid
KW - hepatoprotective agents
KW - liver disease
KW - silibinin
KW - ursodeoxycholic acid
UR - https://www.mendeley.com/catalogue/2193f7e3-5558-3a95-bda0-9f720243164e/
UR - http://www.scopus.com/inward/record.url?scp=85143404213&partnerID=8YFLogxK
U2 - 10.31146/1682-8658-ecg-203-7-5-20
DO - 10.31146/1682-8658-ecg-203-7-5-20
M3 - статья
VL - 203
SP - 5
EP - 20
JO - Экспериментальная и клиническая гастроэнтерология
JF - Экспериментальная и клиническая гастроэнтерология
SN - 1682-8658
IS - 7
ER -
ID: 99493411