Context and relevance. The article provides an overview of current foreign research on burnout from the perspective of clinical psychology. Burnout, a widespread condition associated with workplace stressors in many countries, not only has negative socio-economic consequences, but also presents a range of challenges at various levels of human functioning, including physical and mental health. Objective. To explore various definitions and descriptions of burnout, as well as the main diagnostic criteria for this condition. To analyze the mental disorders and somatic symptoms associated with burnout described in modern studies. To describe the main approaches to the differential diagnosis of burnout and other mental disorders, as well as to analyze the study of biological markers of burnout. Results. The main ways of further research of burnout from the perspective of a biopsychosocial model are outlined. The need for a systematic study of burnout, the establishment of its boundaries from other conditions and the identification of biomarkers for the development of diagnostic criteria is noted