The article examines the system-methodological and conceptual foundations of the psychological activity theory that arose in the Soviet Union under the influence of the ideology of Marxism-Leninism. The author demonstrates the process of incorporation of Marxism-Leninism dogmas into the canonical form of the activity theory as a scientific knowledge that does not need any scientific confirmation. The pseudoscientific discourse that arose at the same time served to strengthen the position of the ideologists of the bureaucratic system, who found “objective confirmations” of the truth of Marx's teachings in the data of psychological science. The scientific community, subjected to ideological transformation, tried to defend itself from the destructive influence of ideology, giving rise to special forms of relations in the scientific and psychological environment, which led to the struggle and confrontation of scientific schools and groups. As a result of ideological expansion, psychological knowledge has become to some extent a tool for the bureaucratic system to overpower scientific dissent. That was clearly manifested in the discussion on the results of the Zagorsk experiment, in which an incorrect, partially falsified, attempt was made to prove the development of the human psyche of children born deaf and blind. The influence of ideology can also be traced in the confrontation of scientific schools in physics, genetics, biology and physiology. The article discusses prospects and new trends in the development of the activity theory after exclusion of the ideological concepts of Soviet socialism from its systemconceptual foundations. We observe the formation of new psychological concepts that reflect non-classical and post-non-classical forms of scientific rationality. Attempts are made to create and study the models of the psyche developed within the framework of the theory of organized complexity and the concepts of autopoietic self-organization and evolution.