The article contains a review of domestic and foreign literature on the use of social networking technologies — analysis of social networks and network interventions — in HIV medicine as promising, cost-effective and sustainable measures to improve HIV prevention and treatment outcomes in the framework of UNAIDS 90-90-90 program. The article described practical experience of using social network analysis to explain differences in the prevalence of HIV infection, including evaluation the behavioral risk levels among persons injecting drugs and the frequency of use of barrier contraceptives. The review reflects examples of the use of the most popular network interventions such as peer education and the Popular Opinion Leader for HIV prevention and for engaging people living with HIV into the medical monitoring and care. In addition, the experience of using innovative social network technologies in St. Petersburg in Russia is described.