pechalnova.alena@gmail.com

Molecular endocrinology (mechanisms of hormonal regulation of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid axes; development of luteinizing hormone and thyrotropin receptor agonists; the search for approaches to correct metabolic dysfunctions, including polycystic ovary syndrome, hypo- and hyperthyroidism and type 2 diabetes mellitus).

Grant Participation

1) RSF No. 19-75-20122 (PI: A.O. Shpakov), 2019–2025 (team member)

Development and study of the mechanisms of action of novel thienopyrimidine-based regulators of the reproductive and thyroid systems

2) RSF No. 23-75-01083 (PI: I.I. Zorina), 2023–2025 (team member)

Investigation of the therapeutic potential of intranasally administered insulin in intact and diabetic rats following ischemic brain injury

3) RSF No. 25-25-01025 (PI: K.V. Derkach), 2026–2027 (team member)

Evaluation of the efficacy and risks of semaglutide use in polycystic ovary syndrome and obesity: focus on ovulation induction and fetal development

Awards

1) First-degree diploma for the paper "Evaluation of the effectiveness of the combined effect of orthosteric and allosteric agonists of the luteinizing hormone receptor on ovulation induction in immature female rats" at the XXXI All-Russian Conference of Young Scientists with International Participation "Current Problems of Biomedicine – 2025."

2) Diploma for the best paper ("Activity, pharmacokinetics, and tissue distribution of an allosteric agonist of the luteinizing hormone receptor, a thieno[2,3-d]-pyrimidine derivative, administered to female rats") at the Scientific and Educational Forum of Young Scientists "Initiative. Energetic. Young!" as part of the All-Russian Scientific and Practical Conference with International Participation "Experimental Medicine – 2025."

3) First-degree diploma for the report "The Effect of TP03, an Allosteric Agonist of the LH/HCG Receptor, on Ovarian Steroidogenesis and Ovulation Induction in Female Rats with DHEA-Induced Polycystic Ovary Syndrome" at the XXXII All-Russian Conference of Young Scientists with International Participation "Current Problems of Biomedicine – 2026."

4) Winner's diploma of the 2026 I.M. Sechenov Young Scientists Competition and the 3rd I.M. Sechenov Prize for 2026 for the project "Evaluation of the Effects of TP03, a Low-Molecular-weight Agonist of the Luteinizing Hormone Receptor, on Steroidogenesis and Ovulation in Female Rats with Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome."

5) Winner of the 2026 competitive selection for the Presidential Scholarship for postgraduate and adjunct students conducting research within the framework of the Russian Federation's scientific and technological development priorities.

6) Diploma for the best poster presentation ("Expression of hypothalamic genes, regulators of the hypothalamic-pituitary-gonadal axis, in rats with polycystic ovary syndrome and the effect of human chorionic gonadotropin treatment") at the III International Congress on Psychophysiology and Psychoneuroendocrinology.

3 years

3 years