TY - JOUR

T1 - Zebrafish models of impulsivity and impulse control disorders

AU - de Abreu, Murilo S

AU - Giacomini, Ana C V V

AU - Genario, Rafael

AU - Fontana, Barbara D

AU - Parker, Matthew O

AU - Marcon, Leticia

AU - Scolari, Naiara

AU - Bueno, Barbara

AU - Demin, Konstantin A

AU - Galstyan, David

AU - Kolesnikova, Tatyana O

AU - Amstislavskaya, Tamara G

AU - Zabegalov, Konstantin N

AU - Strekalova, Tatyana

AU - Kalueff, Allan V

N1 - Publisher Copyright: © 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Impulse control disorders (ICD) are characterized by generalized difficulty controlling emotions and behaviors. ICD are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional-defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD-specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish, and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.

AB - Impulse control disorders (ICD) are characterized by generalized difficulty controlling emotions and behaviors. ICD are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional-defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD-specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish, and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.

KW - aggressiveness

KW - animal models

KW - behavior

KW - central nervous system

KW - genetic models

KW - AGGRESSIVE-BEHAVIOR

KW - NATIONAL COMORBIDITY

KW - CONDUCT DISORDER

KW - DEFICIT HYPERACTIVITY DISORDER

KW - ENVIRONMENTAL ENRICHMENT

KW - NEURAL BASIS

KW - OPPOSITIONAL DEFIANT DISORDER

KW - INTERMITTENT EXPLOSIVE DISORDER

KW - REACTION-TIME-TASK

KW - ANIMAL-MODELS

UR - http://www.scopus.com/inward/record.url?scp=85089001135&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/cd779d55-4ab6-3a5c-a49b-0934b4097e0e/

U2 - 10.1111/ejn.14893

DO - 10.1111/ejn.14893

M3 - Review article

C2 - 32619029

VL - 52

SP - 4233

EP - 4248

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 10

ER -