TY - JOUR

T1 - Zebrafish models for studying central nervous system effects of Ayurvedic medicinal plants

AU - Chakraborty, P

AU - Pal, S

AU - Galstyan, DS

AU - Petersen, E

AU - Amstislavskaya, TG

AU - Kolesnikova, TO

AU - de Abreu, MS

AU - Kalueff, A

N1 - Times Cited in Web of Science Core Collection: 1 Total Times Cited: 1 Cited Reference Count: 103

PY - 2025

Y1 - 2025

N2 - Traditional Indian medicine (Ayurveda) has a long history of treating central nervous system (CNS) disorders. Ayurvedic plants are typically rich in flavonoids, lignans, sterols, tannins and alkaloids that exert potent antiinflammatory, anti-oxidant, neuroprotective and neurotropic effects in both humans and rodents. The zebrafish (Danio rerio) has emerged as a useful model species and a powerful vertebrate in vivo system for CNS disease modeling and drug screening. As zebrafish continue to demonstrate their growing utility for studying a wide range of pharmaceutical therapies, including Chinese and American traditional medicines, here we discuss CNS effects of various Ayurvedic medicinal plants, and how they can be further elucidated using zebrafish models. We also evaluate the existing challenges and limitations of using zebrafish models for studying Ayurvedic pharmacotherapy, as well as outline future directions of translational research in this field.

AB - Traditional Indian medicine (Ayurveda) has a long history of treating central nervous system (CNS) disorders. Ayurvedic plants are typically rich in flavonoids, lignans, sterols, tannins and alkaloids that exert potent antiinflammatory, anti-oxidant, neuroprotective and neurotropic effects in both humans and rodents. The zebrafish (Danio rerio) has emerged as a useful model species and a powerful vertebrate in vivo system for CNS disease modeling and drug screening. As zebrafish continue to demonstrate their growing utility for studying a wide range of pharmaceutical therapies, including Chinese and American traditional medicines, here we discuss CNS effects of various Ayurvedic medicinal plants, and how they can be further elucidated using zebrafish models. We also evaluate the existing challenges and limitations of using zebrafish models for studying Ayurvedic pharmacotherapy, as well as outline future directions of translational research in this field.

KW - Ayurveda

KW - Brain disorders

KW - Zebrafish

KW - Treatment

KW - Novel drugs

KW - WITHANIA-SOMNIFERA

KW - CENTELLA-ASIATICA

KW - ALZHEIMERS-DISEASE

KW - ANTIDEPRESSANT ACTIVITY

KW - NARDOSTACHYS-JATAMANSI

KW - OXIDATIVE STRESS

KW - BACOPA-MONNIERI

KW - ROOT EXTRACT

KW - CURCUMIN

KW - NEUROTOXICITY

U2 - 10.1016/j.jaim.2025.101169

DO - 10.1016/j.jaim.2025.101169

M3 - Article

VL - 16

JO - Journal of Ayurveda and Integrative Medicine

JF - Journal of Ayurveda and Integrative Medicine

SN - 0975-9476

IS - 4

ER -