TY - JOUR

T1 - Zebrafish models: do we have valid paradigms for depression?

AU - de Abreu, Murilo

AU - Friend, Ashton

AU - Демин, Константин Андреевич

AU - Амстиславская, Тамара

AU - Bao, Wandong

AU - Калуев, Алан Валерьевич

N1 - Funding Information: This research was supported by the Russian Foundation for Basic Research (RFBR) grant 1834-00996 to K.A.D. The funders had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Depression is a wide-spread, debilitating psychiatric disorder. Mainly rodent-based, experimental animal models of depression are extensively used to probe the pathogenesis of this disorder. Here, we emphasize the need for innovative approaches to studying depression, and call for a wider use of novel model organisms, such as the zebrafish (Danio rerio), in this field. Highly homologous to humans and rodents, zebrafish are rapidly becoming a valuable tool in translational neuroscience research, but have only recently been utilized in depression research. Multiple conceptual and methodological problems, however, arise in relation to separating putative zebrafish depression-like states from motor and social deficits or anxiety. Here, we examine recent findings and the existing challenges in this field, to encourage further research and the use of zebrafish as novel organisms in cross-species depression modeling.

AB - Depression is a wide-spread, debilitating psychiatric disorder. Mainly rodent-based, experimental animal models of depression are extensively used to probe the pathogenesis of this disorder. Here, we emphasize the need for innovative approaches to studying depression, and call for a wider use of novel model organisms, such as the zebrafish (Danio rerio), in this field. Highly homologous to humans and rodents, zebrafish are rapidly becoming a valuable tool in translational neuroscience research, but have only recently been utilized in depression research. Multiple conceptual and methodological problems, however, arise in relation to separating putative zebrafish depression-like states from motor and social deficits or anxiety. Here, we examine recent findings and the existing challenges in this field, to encourage further research and the use of zebrafish as novel organisms in cross-species depression modeling.

KW - Animal model

KW - Biological psychiatry

KW - Depression

KW - Translational neuroscience

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85051655081&partnerID=8YFLogxK

U2 - 10.1016/j.vascn.2018.07.002

DO - 10.1016/j.vascn.2018.07.002

M3 - Review article

VL - 94

SP - 16

EP - 22

JO - Journal of Pharmacological and Toxicological Methods

JF - Journal of Pharmacological and Toxicological Methods

SN - 1056-8719

ER -