TY - JOUR

T1 - Zebrafish As a Promising Experimental Model of Traumatic Brain Injury

AU - Шевляков, Антон

AU - Ильин, Никита Петрович

AU - Галстян, Давид Самвелович

AU - Колесникова, Татьяна Олеговна

AU - Калуев, Алан Валерьевич

N1 - Shevlyakov, A.D., Ilyin, N.P., Galstyan, D.S. et al. Zebrafish As a Promising Experimental Model of Traumatic Brain Injury. J Evol Biochem Phys 60, 594–611 (2024) // doi.org/10.1134/S0022093024020133

PY - 2024/3/1

Y1 - 2024/3/1

N2 - Traumatic brain injury (TBI) involves multiple types of physical brain lesions. TBI is a highly heterogeneous clinical condition whose symptoms include cognitive, motor and emotional deficits, as well as neurodegeneration and neuroinflammation. TBI modeling in animals plays a key role in studying its pathogenetic mechanisms and temporal dynamics, as well as developing new drugs for its treatment. Recently, the use of the zebrafish Danio rerio as a model organism has aroused the growing interest of translational neurobiology. Zebrafish are now the second most demanded laboratory animal species in biomedicine, after mice. Here, we discuss the prospects of using this teleost fish as a model of TBI, as well as new research trends in this area. We also emphasize the importance of zebrafish as a highly translational model for studying the molecular mechanisms and neurological disorders in TBI, as well as screening for potential therapeutic agents.

AB - Traumatic brain injury (TBI) involves multiple types of physical brain lesions. TBI is a highly heterogeneous clinical condition whose symptoms include cognitive, motor and emotional deficits, as well as neurodegeneration and neuroinflammation. TBI modeling in animals plays a key role in studying its pathogenetic mechanisms and temporal dynamics, as well as developing new drugs for its treatment. Recently, the use of the zebrafish Danio rerio as a model organism has aroused the growing interest of translational neurobiology. Zebrafish are now the second most demanded laboratory animal species in biomedicine, after mice. Here, we discuss the prospects of using this teleost fish as a model of TBI, as well as new research trends in this area. We also emphasize the importance of zebrafish as a highly translational model for studying the molecular mechanisms and neurological disorders in TBI, as well as screening for potential therapeutic agents.

UR - https://www.mendeley.com/catalogue/60a3813b-23b9-3d09-9e37-7ee1686730a2/

U2 - 10.1134/s0022093024020133

DO - 10.1134/s0022093024020133

M3 - Article

VL - 60

SP - 596

EP - 611

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 2

ER -