TY - JOUR

T1 - ZaiS-based colloidal QDs as fluorescent labels for theranostics

T2 - Physical properties, biodistribution and biocompatibility

AU - Istomina, M. S.

AU - Pechnikova, N. A.

AU - Korolev, D. V.

AU - Pochkayeva, E. I.

AU - Mazing, D. S.

AU - Galagudza, M. M.

AU - Moshnikov, V. A.

AU - Shlyakhto, E. V.

N1 - Publisher Copyright: © 2018 Pirogov Russian National Research Medical University. All rights reserved.

PY - 2018

Y1 - 2018

N2 - In recent years there has been an increase in interest in the use of colloidal quantum dots (QDs) in biology and medicine. In particular, QDs can be a perspective nanoscale object for theranostics, in which due to the specific accumulation of drug-loaded QDs in the pathological focus, its simultaneous visualization and targeted therapeutic influence occur. One of the serious limitations of the use of QDs in medicine is their potential toxicity, especially when the nanocrystal material contains elements such as cadmium or plumbum. Therefore, it is promising to develop labels based on QDs of relatively less toxic semiconductors of group I-III-VI, such as CuInS 2 and AgInS 2 . In this study, biodistribution and biocompatibility of QDs based on the AgInS 2 compound with a ZnS shell (ZAIS) are considered. In the study of biodistribution, the accumulation of QDs in organs such as liver, lungs, heart and kidneys was revealed. It was shown that QDs in the dose range from 2 • 10 -7 to 4 • 10 -6 M/L at intravenous administration in rats does not have a significant effect on body mass dynamics and basic hematological parameters for 30 days. Thus, ZAIS QDs can be used to visualize tissues and organs in various pathological processes, and immobilization of the drugs on their surface will allow to approach their application for theranostics.

AB - In recent years there has been an increase in interest in the use of colloidal quantum dots (QDs) in biology and medicine. In particular, QDs can be a perspective nanoscale object for theranostics, in which due to the specific accumulation of drug-loaded QDs in the pathological focus, its simultaneous visualization and targeted therapeutic influence occur. One of the serious limitations of the use of QDs in medicine is their potential toxicity, especially when the nanocrystal material contains elements such as cadmium or plumbum. Therefore, it is promising to develop labels based on QDs of relatively less toxic semiconductors of group I-III-VI, such as CuInS 2 and AgInS 2 . In this study, biodistribution and biocompatibility of QDs based on the AgInS 2 compound with a ZnS shell (ZAIS) are considered. In the study of biodistribution, the accumulation of QDs in organs such as liver, lungs, heart and kidneys was revealed. It was shown that QDs in the dose range from 2 • 10 -7 to 4 • 10 -6 M/L at intravenous administration in rats does not have a significant effect on body mass dynamics and basic hematological parameters for 30 days. Thus, ZAIS QDs can be used to visualize tissues and organs in various pathological processes, and immobilization of the drugs on their surface will allow to approach their application for theranostics.

KW - Biocompatibility

KW - Biodistribution

KW - Colloidal quantum dots

KW - QDs

KW - Theranostics

KW - ZAIS

KW - ZnS-AgInS

UR - http://www.scopus.com/inward/record.url?scp=85064279471&partnerID=8YFLogxK

U2 - 10.24075/brsmu.2018.073

DO - 10.24075/brsmu.2018.073

M3 - Article

AN - SCOPUS:85064279471

VL - 7

SP - 94

EP - 101

JO - Bulletin of Russian State Medical University

JF - Bulletin of Russian State Medical University

SN - 2500-1094

IS - 6

ER -