Результаты исследований: Научные публикации в периодических изданиях › статья
Y/15 and Y/22 Derivative Chromosomes in Couples with Reproductive Failures: Algorithm of Preimplantation Genetic Testing and Specificity of Inheritance. / Puppo, I. L.; Saifitdinova, A. F.; Loginova, Y. A.; Kinunen, A. A.; Tonyan, Z. N.; Leontyeva, O. A.; Chiryaeva, O. G.; Pendina, A. A.; Efimova, O. A.; Tikhonov, A. V.; Petrovskaia-Kaminskaia, A. V.; Dudkina, V. S.; Bichevaya, N. K.
в: Russian Journal of Genetics, Том 56, № 4, 2020, стр. 488-495.Результаты исследований: Научные публикации в периодических изданиях › статья
}
TY - JOUR
T1 - Y/15 and Y/22 Derivative Chromosomes in Couples with Reproductive Failures: Algorithm of Preimplantation Genetic Testing and Specificity of Inheritance.
AU - Puppo, I. L.
AU - Saifitdinova, A. F.
AU - Loginova, Y. A.
AU - Kinunen, A. A.
AU - Tonyan, Z. N.
AU - Leontyeva, O. A.
AU - Chiryaeva, O. G.
AU - Pendina, A. A.
AU - Efimova, O. A.
AU - Tikhonov, A. V.
AU - Petrovskaia-Kaminskaia, A. V.
AU - Dudkina, V. S.
AU - Bichevaya, N. K.
PY - 2020
Y1 - 2020
N2 - The present study reports on the results of preimplantation genetic testing and IVF outcomes in four families, where one of the spouses is a carrier of Y/15 or Y/22 derivative chromosome: three cases of male carriers and one—of female carrier. In the cases of male carriers, we detected the predominant inheritance of the derivative chromosomes by the embryos and no abnormalities in sex chromosome segregation. In the case of female carrier, we did not observe either predominant inheritance of derivative chromosome by the embryos or effect of derivative chromosome on sex chromosome segregation. In all families, we revealed a high frequency of embryonic aneuploidies of chromosomes other than those involved in translocation. To exclude inheritance of the derivative chromosome by the offspring, preimplantation genetic testing should be recommended: fluorescent in situ hybridization (FISH), which allows identification of the Y-chromosome satellite DNA, followed by next generation sequencing (NGS) or microarray compa
AB - The present study reports on the results of preimplantation genetic testing and IVF outcomes in four families, where one of the spouses is a carrier of Y/15 or Y/22 derivative chromosome: three cases of male carriers and one—of female carrier. In the cases of male carriers, we detected the predominant inheritance of the derivative chromosomes by the embryos and no abnormalities in sex chromosome segregation. In the case of female carrier, we did not observe either predominant inheritance of derivative chromosome by the embryos or effect of derivative chromosome on sex chromosome segregation. In all families, we revealed a high frequency of embryonic aneuploidies of chromosomes other than those involved in translocation. To exclude inheritance of the derivative chromosome by the offspring, preimplantation genetic testing should be recommended: fluorescent in situ hybridization (FISH), which allows identification of the Y-chromosome satellite DNA, followed by next generation sequencing (NGS) or microarray compa
M3 - Article
VL - 56
SP - 488
EP - 495
JO - Russian Journal of Genetics
JF - Russian Journal of Genetics
SN - 1022-7954
IS - 4
ER -
ID: 78491087