TY - JOUR

T1 - What changes in perfusion and myocardial function after late revascularization of acute myocardial infarction?

AU - Ostroumov, E. N.

AU - Migunova, E. V.

AU - Kotina, E. D.

AU - Sinyakova, O. G.

AU - Gazaryan, G. A.

AU - Ryabinin, V. A.

AU - Kudryashova, N. E.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - AIM: To determine the influence of the time gap between acute myocardial infarction with ST-segment elevation and intracoronary intervention performed later than 2.5 hours on myocardium, we studied indicators of perfusion over time with an aid of SPECT, including intraventricular asynchrony (2-4 days and 6-8 months after stent installation). MATERIALS AND METHOD: We observed 22 patients with multivessel coronary lesion. The Russian program with the analysis of perfusion, function and the phase images was used in SPECT synchronized with ECG. RESULTS: Showed that the time gap prior to coronary intervention in the acute phase of myocardial infarction may be directly connected with the increase in impaired perfusion during the end-systole and the severity of pathological intraventricular asynchrony without ECG signs. All patients had significantly decreased wall mobility and intraventricular asynchrony together with increased R-R interval in the late period (after 6-8 months) independently from the coronary intervention time. In patients of group 1 (coronary intervention within 6 hours), focal transmural lesions of myocardium significantly decreased. CONCLUSION: Late revascularization help decrease intraventricular asynchrony reducing the risk of heart failure in future.

AB - AIM: To determine the influence of the time gap between acute myocardial infarction with ST-segment elevation and intracoronary intervention performed later than 2.5 hours on myocardium, we studied indicators of perfusion over time with an aid of SPECT, including intraventricular asynchrony (2-4 days and 6-8 months after stent installation). MATERIALS AND METHOD: We observed 22 patients with multivessel coronary lesion. The Russian program with the analysis of perfusion, function and the phase images was used in SPECT synchronized with ECG. RESULTS: Showed that the time gap prior to coronary intervention in the acute phase of myocardial infarction may be directly connected with the increase in impaired perfusion during the end-systole and the severity of pathological intraventricular asynchrony without ECG signs. All patients had significantly decreased wall mobility and intraventricular asynchrony together with increased R-R interval in the late period (after 6-8 months) independently from the coronary intervention time. In patients of group 1 (coronary intervention within 6 hours), focal transmural lesions of myocardium significantly decreased. CONCLUSION: Late revascularization help decrease intraventricular asynchrony reducing the risk of heart failure in future.

KW - Acute myocardial infarction

KW - SPECT synchronized with ECG, intraventricular asynchrony

UR - http://www.scopus.com/inward/record.url?scp=85045568576&partnerID=8YFLogxK

U2 - 10.23934/2223-9022-2017-6-2-118-123

DO - 10.23934/2223-9022-2017-6-2-118-123

M3 - Article

AN - SCOPUS:85045568576

VL - 6

SP - 118

EP - 123

JO - Russian Sklifosovsky Journal of Emergency Medical Care

JF - Russian Sklifosovsky Journal of Emergency Medical Care

SN - 2223-9022

IS - 2

ER -