TY - JOUR

T1 - Vliianie sinteticheskogo antioksidanta ubinona-9 na intensivenost' perekisnogo okisleniia lipidov v thrombotsitakh i plazme krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa

AU - Shatilina, L V

AU - Borisenko, L V

AU - Balliuzek, M F

AU - Gurevich, V S

PY - 1989

Y1 - 1989

N2 - The antioxidant ubinon-9 was tested for its effects on platelet and plasma lipid peroxidation parameters in patients with acute ischemic heart diseases. The use of ubinon-9 in the multimodality therapy of patients with ischemic heart disease was shown to result in a significant decrease in lipid peroxidation intensity by enhancing superoxide dismutase activity in the platelets and plasma from the patients. Ubinon-9 equally prevented lipid peroxidation activation during enzymatic and nonenzymatic induction in the platelets of patients with unstable angina or acute myocardial infarction. Unlike a daily dose of 30 mg, 90 mg a day is a more effective dose in reducing platelet and plasma lipid peroxidation parameters. One may suggest that addition of ubinon-9 into the routine treatment regimen allows the therapy for acute ischemic heart disease to be optimize.

AB - The antioxidant ubinon-9 was tested for its effects on platelet and plasma lipid peroxidation parameters in patients with acute ischemic heart diseases. The use of ubinon-9 in the multimodality therapy of patients with ischemic heart disease was shown to result in a significant decrease in lipid peroxidation intensity by enhancing superoxide dismutase activity in the platelets and plasma from the patients. Ubinon-9 equally prevented lipid peroxidation activation during enzymatic and nonenzymatic induction in the platelets of patients with unstable angina or acute myocardial infarction. Unlike a daily dose of 30 mg, 90 mg a day is a more effective dose in reducing platelet and plasma lipid peroxidation parameters. One may suggest that addition of ubinon-9 into the routine treatment regimen allows the therapy for acute ischemic heart disease to be optimize.

KW - Adult

KW - Angina, Unstable/drug therapy

KW - Antioxidants/administration & dosage

KW - Blood Platelets/drug effects

KW - Coronary Disease/blood

KW - Humans

KW - Lipid Peroxidation/drug effects

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/drug therapy

KW - Organic Chemicals

KW - Superoxide Dismutase/blood

M3 - статья

C2 - 2615186

VL - 29

SP - 91

EP - 95

JO - КАРДИОЛОГИЯ

JF - КАРДИОЛОГИЯ

SN - 0022-9040

IS - 11

ER -