TY - JOUR

T1 - Vitamine D et cognition chez la personne âgée

T2 - Consensus et recommandations d'un groupe d'experts internationaux

AU - Annweiler, Cédric

AU - Dursun, Erdinç

AU - Féron, Francois

AU - Gezen-Ak, Duygu

AU - Kalueff, Allan V.

AU - Littlejohns, Thomas

AU - Llewellyn, David

AU - Millet, Pascal

AU - Scott, Tammy

AU - Tucker, Katherine L.

AU - Yilmazer, Selma

AU - Beauchet, Olivier

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: Hypovitaminosis D, a common condition in older adults, is associated with brain changes and dementia. Given the fast growing contribution of literature in this research field, clear guidance is needed for clinicians and researchers. Methods: International experts met at the invitational summit on "Vitamin D and cognition in older adults" in Boston, MA, July 2013. Based upon literature and expert opinion, the task force focused on key questions on the role of vitamin D in Alzheimer disease and related disorders. Each question was discussed and voted using a Delphi-like approach. Results: Experts reached agreement that hypovitaminosis D increases the risk of cognitive decline and dementia in older adults, may alter the clinical presentation as a consequence of related comorbidities, but should not be used thus far as a diagnostic or prognostic biomarker of Alzheimer disease due to lack of specificity and insufficient evidence. Hypovitaminosis D should be screened in this population because of its high prevalence and supplemented, if necessary, but this advice was not specific to cognition. Conclusions. The task force agreed on 5 overarching principles related to vitamin D and cognition in older adults.

AB - Background: Hypovitaminosis D, a common condition in older adults, is associated with brain changes and dementia. Given the fast growing contribution of literature in this research field, clear guidance is needed for clinicians and researchers. Methods: International experts met at the invitational summit on "Vitamin D and cognition in older adults" in Boston, MA, July 2013. Based upon literature and expert opinion, the task force focused on key questions on the role of vitamin D in Alzheimer disease and related disorders. Each question was discussed and voted using a Delphi-like approach. Results: Experts reached agreement that hypovitaminosis D increases the risk of cognitive decline and dementia in older adults, may alter the clinical presentation as a consequence of related comorbidities, but should not be used thus far as a diagnostic or prognostic biomarker of Alzheimer disease due to lack of specificity and insufficient evidence. Hypovitaminosis D should be screened in this population because of its high prevalence and supplemented, if necessary, but this advice was not specific to cognition. Conclusions. The task force agreed on 5 overarching principles related to vitamin D and cognition in older adults.

KW - Alzheimer disease

KW - Brain

KW - Cognition

KW - Neuroendocrinology

KW - Older adults

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85000936691&partnerID=8YFLogxK

U2 - 10.1684/pnv.2016.0613

DO - 10.1684/pnv.2016.0613

M3 - статья

AN - SCOPUS:85000936691

VL - 14

SP - 265

EP - 273

JO - Geriatrie et Psychologie Neuropsychiatrie du Vieillissement

JF - Geriatrie et Psychologie Neuropsychiatrie du Vieillissement

SN - 2115-8789

IS - 3

ER -