TY - JOUR

T1 - Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing

AU - Fontana, Barbara D

AU - Müller, Talise E

AU - Cleal, Madeleine

AU - de Abreu, Murilo S

AU - Norton, William H J

AU - Demin, Konstantin A

AU - Amstislavskaya, Tamara G

AU - Petersen, Elena V

AU - Kalueff, Allan V

AU - Parker, Matthew O

AU - Rosemberg, Denis B

N1 - Funding Information: This study was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Finance Code 001 at the University of Portsmouth, UK (BDF). DBR receives the CNPq research productivity grant (305051/2018-0) and his work is also supported by FAPERGS Programa Pesquisador Gaúcho – PQG fellowship grant (process number 19/2551-0001764-2) and PROEX/CAPES fellowship grant (23038.005450/2020-19). AVK is supported by the Southwest University Zebrafish Platform Construction Funds . KAD is supported by the Fellowship of the President of Russia and Special Rector’s Fellowship for SPSU PhD Students. The laboratory is supported by the Russian Science Foundation (RSF) grant 19-15-00053 and state budgetary research project 51130521 from St. Petersburg State University. TGA is supported by the RSF grant 20-65-46006. MOP receives funding from the Foundation for Liver Research (UK), Alzheimer’s Research UK, and INTERREG (EU). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. This multi-laboratory collaborative study resulted from a Special 2020 Task Force, based on scientific discussions during the I International Zebrafish Neuroscience Web Conference (2020).

PY - 2022/1

Y1 - 2022/1

N2 - Social behavior represents a beneficial interaction between conspecifics that is critical for maintaining health and wellbeing. Dysfunctional or poor social interaction are associated with increased risk of physical (e.g., vascular) and psychiatric disorders (e.g., anxiety, depression, and substance abuse). Although the impact of negative and positive social interactions is well-studied, their underlying mechanisms remain poorly understood. Zebrafish have well-characterized social behavior phenotypes, high genetic homology with humans, relative experimental simplicity and the potential for high-throughput screens. Here, we discuss the use of zebrafish as a candidate model organism for studying the fundamental mechanisms underlying social interactions, as well as potential impacts of social isolation on human health and wellbeing. Overall, the growing utility of zebrafish models may improve our understanding of how the presence and absence of social interactions can differentially modulate various molecular and physiological biomarkers, as well as a wide range of other behaviors.

AB - Social behavior represents a beneficial interaction between conspecifics that is critical for maintaining health and wellbeing. Dysfunctional or poor social interaction are associated with increased risk of physical (e.g., vascular) and psychiatric disorders (e.g., anxiety, depression, and substance abuse). Although the impact of negative and positive social interactions is well-studied, their underlying mechanisms remain poorly understood. Zebrafish have well-characterized social behavior phenotypes, high genetic homology with humans, relative experimental simplicity and the potential for high-throughput screens. Here, we discuss the use of zebrafish as a candidate model organism for studying the fundamental mechanisms underlying social interactions, as well as potential impacts of social isolation on human health and wellbeing. Overall, the growing utility of zebrafish models may improve our understanding of how the presence and absence of social interactions can differentially modulate various molecular and physiological biomarkers, as well as a wide range of other behaviors.

KW - Anxiety

KW - Depression

KW - Social interactions

KW - Social isolation

KW - Translational models

KW - Zebrafish

KW - Humans

KW - Mental Health

KW - Social Interaction

KW - Animals

KW - Zebrafish/physiology

KW - Behavior, Animal/physiology

KW - Social Behavior

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=85099804329&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d98c77ec-28ca-3a34-89c1-9db1155a0a4f/

U2 - 10.1016/j.pneurobio.2021.101993

DO - 10.1016/j.pneurobio.2021.101993

M3 - Review article

C2 - 33440208

VL - 208

SP - 101993

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

M1 - 101993

ER -