Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis. / Кравченко, Анастасия Витальевна; Колобова, Екатерина Алексеевна; Карцова, Людмила Алексеевна.
в: Monatshefte für Chemie - Chemical Monthly, Том 152, № 9, 09.2021, стр. 1067–1074.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis
AU - Кравченко, Анастасия Витальевна
AU - Колобова, Екатерина Алексеевна
AU - Карцова, Людмила Алексеевна
N1 - Publisher Copyright: © 2021, Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Nowadays, there are plenty of approaches to determine steroids hormones by capillary electrophoresis, however, the development of new ones is still actual. In the present study, the possibilities of 3-methyl-1-β-cyclodextrinimidazole tosylate as pseudo stationary phase are considered. Due to the formation of positively charged complexes between steroids with a derivative based on β-cyclodextrin and imidazolium cation, the following results were achieved: first, it was established that adding of this modifier at concentration 0.70 mM at pH 3.2 allowed to separate the five most important corticosteroid hormones (cortisone, hydrocortisone, 11-deoxycortisol, corticosterone, 21-hydroxyprogesterone). Second, the presence of a modifier in the sample permitted to carry out electrokinetic injection of samples and preconcentration of analytes under field-amplified sample injection mode. Obtained values of limits of detection (5–15 ng/cm 3) allowed to analyze plasma samples after liquid–liquid extraction by chloroform. Graphic abstract: [Figure not available: see fulltext.]
AB - Nowadays, there are plenty of approaches to determine steroids hormones by capillary electrophoresis, however, the development of new ones is still actual. In the present study, the possibilities of 3-methyl-1-β-cyclodextrinimidazole tosylate as pseudo stationary phase are considered. Due to the formation of positively charged complexes between steroids with a derivative based on β-cyclodextrin and imidazolium cation, the following results were achieved: first, it was established that adding of this modifier at concentration 0.70 mM at pH 3.2 allowed to separate the five most important corticosteroid hormones (cortisone, hydrocortisone, 11-deoxycortisol, corticosterone, 21-hydroxyprogesterone). Second, the presence of a modifier in the sample permitted to carry out electrokinetic injection of samples and preconcentration of analytes under field-amplified sample injection mode. Obtained values of limits of detection (5–15 ng/cm 3) allowed to analyze plasma samples after liquid–liquid extraction by chloroform. Graphic abstract: [Figure not available: see fulltext.]
KW - Capillary electrophoresis
KW - Cyclodextrins
KW - Ionic liquids
KW - Macrocycles
KW - On-line preconcentration
KW - Steroids
KW - STEROIDS
KW - ELECTROKINETIC CHROMATOGRAPHY
KW - CYCLODEXTRINS
UR - http://www.scopus.com/inward/record.url?scp=85112554450&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/493ddb31-2b1e-3d54-afd6-cf89a0759961/
U2 - 10.1007/s00706-021-02809-4
DO - 10.1007/s00706-021-02809-4
M3 - Article
VL - 152
SP - 1067
EP - 1074
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
SN - 0026-9247
IS - 9
ER -
ID: 86617447