Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis

Standard

Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis. / Кравченко, Анастасия Витальевна; Колобова, Екатерина Алексеевна ; Карцова, Людмила Алексеевна.

в: Monatshefte für Chemie - Chemical Monthly, Том 152, № 9, 09.2021, стр. 1067–1074.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{fcac62200b8a4f7997feca9098ed4752,

title = "Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis",

abstract = "Nowadays, there are plenty of approaches to determine steroids hormones by capillary electrophoresis, however, the development of new ones is still actual. In the present study, the possibilities of 3-methyl-1-β-cyclodextrinimidazole tosylate as pseudo stationary phase are considered. Due to the formation of positively charged complexes between steroids with a derivative based on β-cyclodextrin and imidazolium cation, the following results were achieved: first, it was established that adding of this modifier at concentration 0.70 mM at pH 3.2 allowed to separate the five most important corticosteroid hormones (cortisone, hydrocortisone, 11-deoxycortisol, corticosterone, 21-hydroxyprogesterone). Second, the presence of a modifier in the sample permitted to carry out electrokinetic injection of samples and preconcentration of analytes under field-amplified sample injection mode. Obtained values of limits of detection (5–15 ng/cm 3) allowed to analyze plasma samples after liquid–liquid extraction by chloroform. Graphic abstract: [Figure not available: see fulltext.] ",

keywords = "Capillary electrophoresis, Cyclodextrins, Ionic liquids, Macrocycles, On-line preconcentration, Steroids, STEROIDS, ELECTROKINETIC CHROMATOGRAPHY, CYCLODEXTRINS",

author = "Кравченко, {Анастасия Витальевна} and Колобова, {Екатерина Алексеевна} and Карцова, {Людмила Алексеевна}",

note = "Publisher Copyright: {\textcopyright} 2021, Springer-Verlag GmbH Austria, part of Springer Nature.",

year = "2021",

month = sep,

doi = "10.1007/s00706-021-02809-4",

language = "English",

volume = "152",

pages = "1067–1074",

journal = "Monatshefte fur Chemie",

issn = "0026-9247",

publisher = "Springer Nature",

number = "9",

}

RIS

TY - JOUR

T1 - Usage of 3-methyl-1-β-cyclodextrinimidazole tosylate for electrophoretic separation and preconcentration of corticosteroids by capillary electrophoresis

AU - Кравченко, Анастасия Витальевна

AU - Колобова, Екатерина Алексеевна

AU - Карцова, Людмила Алексеевна

PY - 2021/9

Y1 - 2021/9

N2 - Nowadays, there are plenty of approaches to determine steroids hormones by capillary electrophoresis, however, the development of new ones is still actual. In the present study, the possibilities of 3-methyl-1-β-cyclodextrinimidazole tosylate as pseudo stationary phase are considered. Due to the formation of positively charged complexes between steroids with a derivative based on β-cyclodextrin and imidazolium cation, the following results were achieved: first, it was established that adding of this modifier at concentration 0.70 mM at pH 3.2 allowed to separate the five most important corticosteroid hormones (cortisone, hydrocortisone, 11-deoxycortisol, corticosterone, 21-hydroxyprogesterone). Second, the presence of a modifier in the sample permitted to carry out electrokinetic injection of samples and preconcentration of analytes under field-amplified sample injection mode. Obtained values of limits of detection (5–15 ng/cm 3) allowed to analyze plasma samples after liquid–liquid extraction by chloroform. Graphic abstract: [Figure not available: see fulltext.]

AB - Nowadays, there are plenty of approaches to determine steroids hormones by capillary electrophoresis, however, the development of new ones is still actual. In the present study, the possibilities of 3-methyl-1-β-cyclodextrinimidazole tosylate as pseudo stationary phase are considered. Due to the formation of positively charged complexes between steroids with a derivative based on β-cyclodextrin and imidazolium cation, the following results were achieved: first, it was established that adding of this modifier at concentration 0.70 mM at pH 3.2 allowed to separate the five most important corticosteroid hormones (cortisone, hydrocortisone, 11-deoxycortisol, corticosterone, 21-hydroxyprogesterone). Second, the presence of a modifier in the sample permitted to carry out electrokinetic injection of samples and preconcentration of analytes under field-amplified sample injection mode. Obtained values of limits of detection (5–15 ng/cm 3) allowed to analyze plasma samples after liquid–liquid extraction by chloroform. Graphic abstract: [Figure not available: see fulltext.]

KW - Capillary electrophoresis

KW - Cyclodextrins

KW - Ionic liquids

KW - Macrocycles

KW - On-line preconcentration

KW - Steroids

KW - STEROIDS

KW - ELECTROKINETIC CHROMATOGRAPHY

KW - CYCLODEXTRINS

UR - http://www.scopus.com/inward/record.url?scp=85112554450&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/493ddb31-2b1e-3d54-afd6-cf89a0759961/

U2 - 10.1007/s00706-021-02809-4

DO - 10.1007/s00706-021-02809-4

M3 - Article

VL - 152

SP - 1067

EP - 1074

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

SN - 0026-9247

IS - 9

ER -

ID: 86617447