TY - JOUR

T1 - Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets

AU - Zdravkova, Kristina

AU - Mijanovic, Olja

AU - Brankovic, Ana

AU - Ilicheva, Polina M.

AU - Jakovleva, Aleksandra

AU - Karanovic, Jelena

AU - Pualic, Milena

AU - Pualic, Dusan

AU - Rubel, Aleksandr A.

AU - Savvateeva, Lyudmila V.

AU - Parodi, Alessandro

AU - Zamyatnin, Andrey A.

N1 - Zdravkova K, Mijanovic O, Brankovic A, Ilicheva PM, Jakovleva A, Karanovic J, Pualic M, Pualic D, Rubel AA, Savvateeva LV, et al. Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets. Cells. 2024; 13(11):917. https://doi.org/10.3390/cells13110917

PY - 2024/5/25

Y1 - 2024/5/25

N2 - Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targeting these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances.

AB - Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targeting these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances.

KW - Cysteine cathepsins

KW - Pathology

KW - Therapy

KW - Inhibitors

KW - Animals

KW - Cathepsin F/metabolism

KW - Cathepsins/metabolism

KW - Cysteine Proteases/metabolism

KW - Humans

KW - Neoplasms/drug therapy

KW - Substrate Specificity

KW - inhibitors

KW - pathology

KW - therapy

KW - cysteine cathepsins

UR - https://www.mendeley.com/catalogue/f3aec9e2-959b-35fe-938d-464cbaf6acc1/

U2 - 10.3390/cells13110917

DO - 10.3390/cells13110917

M3 - Review article

C2 - 38891048

VL - 13

JO - Cells

JF - Cells

SN - 2073-4409

IS - 11

M1 - 917

ER -