TY - JOUR

T1 - Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?

AU - Stewart, A. M.

AU - Nguyen, M.

AU - Song, C.

AU - Kalueff, A. V.

PY - 2015

Y1 - 2015

N2 - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

AB - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

KW - Brain disorder

KW - endophenotype

KW - neuropsychiatric domain

KW - pathogenetic interplay/overlap

KW - spectrum of brain disorders

U2 - 10.1177/0269881115593904

DO - 10.1177/0269881115593904

M3 - Literature review

VL - 29

SP - 872

EP - 877

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 8

ER -