We present an asymptotic derivation of the two-dimensional equations of equilibrium of a thin elastic inhomogeneous plate manufactured of an anisotropic material of general form with 21 moduli of elasticity. We also consider simplified models obtained under special assumptions on the moduli. We use test examples to illustrate the error estimate of the proposed model and discuss its scope. The model is compared with the classical Kirchhoff–Love and Timoshenko–Reissner models.