TY - JOUR

T1 - Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera)

AU - Borisenko, I.E.

AU - Adamska, M.

AU - Tokina, D.B.

AU - Ereskovsky, A.V.

PY - 2015

Y1 - 2015

N2 - The ability to regenerate is widespread in the animal kingdom, but the regenerative capacities and mechanisms vary widely. To understand the evolutionary history of the diverse regeneration mechanisms, the regeneration processes must be studied in early-evolved metazoans in addition to the traditional bilaterian and cnidarian models. For this purpose, we have combined several microscopy techniques to study mechanisms of regeneration in the demosponge Halisarca dujardini. The objectives of this work are to detect the cells and morphogenetic processes involved in Halisarca regeneration.We show that in Halisarca there are three main sources of the new exopinacodermduring regeneration: choanocytes, archaeocytes and (rarely) endopinacocytes. Here we show that epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) occur during Halisarca regeneration. EMT is the principal mechanism during the first stages of regeneration, soon after the injury. Epithelial cells from damaged and adj

AB - The ability to regenerate is widespread in the animal kingdom, but the regenerative capacities and mechanisms vary widely. To understand the evolutionary history of the diverse regeneration mechanisms, the regeneration processes must be studied in early-evolved metazoans in addition to the traditional bilaterian and cnidarian models. For this purpose, we have combined several microscopy techniques to study mechanisms of regeneration in the demosponge Halisarca dujardini. The objectives of this work are to detect the cells and morphogenetic processes involved in Halisarca regeneration.We show that in Halisarca there are three main sources of the new exopinacodermduring regeneration: choanocytes, archaeocytes and (rarely) endopinacocytes. Here we show that epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) occur during Halisarca regeneration. EMT is the principal mechanism during the first stages of regeneration, soon after the injury. Epithelial cells from damaged and adj

KW - Sponges

KW - Regeneration

KW - Morphogenesis

KW - Epithelial-to-mesenchymal transition

KW - Transdifferentiation

KW - Halisarca dujardini

U2 - 10.7717/peerj.1211

DO - 10.7717/peerj.1211

M3 - Article

VL - 3:e1211

SP - 1

EP - 23

JO - PeerJ

JF - PeerJ

SN - 2167-8359

ER -