Trace Amines and Their Receptors: Historical Context and Contribution of Genetic Models to Research

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Trace Amines and Their Receptors: Historical Context and Contribution of Genetic Models to Research. / Муртазина, Рамиля Зуфаровна ; Нифантова, Наталья Владимировна ; Гайнетдинов, Рауль Радикович.

в: Russian Journal of Genetics, Том 61, № 11, 01.11.2025, стр. 1533–1540.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

BibTeX

@article{ee1e2b580ab14c3b92ea7e6065b23f8b,

title = "Trace Amines and Their Receptors: Historical Context and Contribution of Genetic Models to Research",

abstract = "Abstract: Trace amines—low-molecular-weight endogenous compounds structurally similar to monoamine neurotransmitters—were long considered mere byproducts of amino acid metabolism. However, the 2001 discovery of a family of specific receptors coupled with G proteins and trace amine-associated receptors (TAARs) prompted a reevaluation of their role in regulating physiological processes. This review outlines key milestones in the study of trace amines and their receptors, with particular emphasis on the contribution of animal genetic models. These models have been instrumental both in identifying physiological processes involving trace amines and in elucidating the molecular mechanisms underlying their action.",

keywords = "GPCR, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, trace amines",

author = "Муртазина, {Рамиля Зуфаровна} and Нифантова, {Наталья Владимировна} and Гайнетдинов, {Рауль Радикович}",

year = "2025",

month = nov,

day = "1",

doi = "10.1134/s1022795425701091",

language = "English",

volume = "61",

pages = "1533–1540",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "11",

}

RIS

TY - JOUR

T1 - Trace Amines and Their Receptors: Historical Context and Contribution of Genetic Models to Research

AU - Муртазина, Рамиля Зуфаровна

AU - Нифантова, Наталья Владимировна

AU - Гайнетдинов, Рауль Радикович

PY - 2025/11/1

Y1 - 2025/11/1

N2 - Abstract: Trace amines—low-molecular-weight endogenous compounds structurally similar to monoamine neurotransmitters—were long considered mere byproducts of amino acid metabolism. However, the 2001 discovery of a family of specific receptors coupled with G proteins and trace amine-associated receptors (TAARs) prompted a reevaluation of their role in regulating physiological processes. This review outlines key milestones in the study of trace amines and their receptors, with particular emphasis on the contribution of animal genetic models. These models have been instrumental both in identifying physiological processes involving trace amines and in elucidating the molecular mechanisms underlying their action.

AB - Abstract: Trace amines—low-molecular-weight endogenous compounds structurally similar to monoamine neurotransmitters—were long considered mere byproducts of amino acid metabolism. However, the 2001 discovery of a family of specific receptors coupled with G proteins and trace amine-associated receptors (TAARs) prompted a reevaluation of their role in regulating physiological processes. This review outlines key milestones in the study of trace amines and their receptors, with particular emphasis on the contribution of animal genetic models. These models have been instrumental both in identifying physiological processes involving trace amines and in elucidating the molecular mechanisms underlying their action.

KW - GPCR

KW - TAAR1

KW - TAAR2

KW - TAAR5

KW - TAAR6

KW - TAAR8

KW - TAAR9

KW - trace amines

UR - https://www.mendeley.com/catalogue/c950434d-74fb-34a6-a3f3-b7ff155246e9/

U2 - 10.1134/s1022795425701091

DO - 10.1134/s1022795425701091

M3 - Review article

VL - 61

SP - 1533

EP - 1540

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 11

ER -

ID: 144898284