TY - JOUR

T1 - Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

AU - Vaganova, Anastasia N.

AU - Shemyakova, Taisiia S.

AU - Lenskaia, Karina V.

AU - Rodionov, Roman N.

AU - Steenblock, Charlotte

AU - Gainetdinov, Raul R.

PY - 2023/11/5

Y1 - 2023/11/5

N2 - In the 21st century, the prevalence of the metabolic syndrome is becoming an epidemic, while pharmacological treatment is reduced to alleviating symptoms, and a systematic approach is to change lifestyle. Along this line, the search, study, and development of effective therapeutic agents against metabolic syndrome is an extremely urgent task. The trace aminergic system modulates dopamine neurotransmission, which is one of the critical links in the pathogenesis of this disorder. The expression of trace amine-associated receptors (TAARs) in tissues associated with energy and metabolism suggests their role in metabolic syndrome. In particular, this modulatory system may regulate insulin secretion in pancreatic islets β-cells. Through these facts, the trace amine-related regulatory pathways seem to be prospective therapeutic targets for metabolic syndrome correction. In particular, the accumulating data demonstrates the positive effect of trace amine-associated receptor 1 (TAAR1) agonists on the dynamics of the metabolic syndrome, concomitant diseases, and factors of its pathogenesis. In this review, we summarize the evidence of TAARs contribution to metabolic syndrome pathogenesis and regulation of insulin secretion in pancreatic islets. By analyzing public transcriptomic data, we also expound on the involvement of the TAAR1 and other TAAR receptors (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) in the pancreatic islet functions and its possible significance for the normal functioning of these complex heterogeneous structures.

AB - In the 21st century, the prevalence of the metabolic syndrome is becoming an epidemic, while pharmacological treatment is reduced to alleviating symptoms, and a systematic approach is to change lifestyle. Along this line, the search, study, and development of effective therapeutic agents against metabolic syndrome is an extremely urgent task. The trace aminergic system modulates dopamine neurotransmission, which is one of the critical links in the pathogenesis of this disorder. The expression of trace amine-associated receptors (TAARs) in tissues associated with energy and metabolism suggests their role in metabolic syndrome. In particular, this modulatory system may regulate insulin secretion in pancreatic islets β-cells. Through these facts, the trace amine-related regulatory pathways seem to be prospective therapeutic targets for metabolic syndrome correction. In particular, the accumulating data demonstrates the positive effect of trace amine-associated receptor 1 (TAAR1) agonists on the dynamics of the metabolic syndrome, concomitant diseases, and factors of its pathogenesis. In this review, we summarize the evidence of TAARs contribution to metabolic syndrome pathogenesis and regulation of insulin secretion in pancreatic islets. By analyzing public transcriptomic data, we also expound on the involvement of the TAAR1 and other TAAR receptors (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) in the pancreatic islet functions and its possible significance for the normal functioning of these complex heterogeneous structures.

KW - Amines/metabolism

KW - Humans

KW - Insulin Secretion

KW - Islets of Langerhans/metabolism

KW - Metabolic Syndrome/metabolism

KW - Receptors, G-Protein-Coupled/genetics

KW - Signal Transduction

UR - https://www.mendeley.com/catalogue/07741406-e3a6-3d0b-ad19-73446125242f/

U2 - 10.3390/biom13111618

DO - 10.3390/biom13111618

M3 - Review article

C2 - 38002300

VL - 13

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 11

M1 - 1618

ER -