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Towards Zebrafish Models of CNS Channelopathies. / Колесникова, Татьяна Олеговна; Демин, Константин Андреевич; Costa, Fabiano V.; Забегалов, Константин Николаевич; de Abreu, Murilo S; Герасимова, Елена; Калуев, Алан Валерьевич.

в: International Journal of Molecular Sciences, Том 23, № 22, 13979, 12.11.2022.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Колесникова, ТО, Демин, КА, Costa, FV, Забегалов, КН, de Abreu, MS, Герасимова, Е & Калуев, АВ 2022, 'Towards Zebrafish Models of CNS Channelopathies', International Journal of Molecular Sciences, Том. 23, № 22, 13979. https://doi.org/10.3390/ijms232213979

APA

Колесникова, Т. О., Демин, К. А., Costa, F. V., Забегалов, К. Н., de Abreu, M. S., Герасимова, Е., & Калуев, А. В. (2022). Towards Zebrafish Models of CNS Channelopathies. International Journal of Molecular Sciences, 23(22), [13979]. https://doi.org/10.3390/ijms232213979

Vancouver

Колесникова ТО, Демин КА, Costa FV, Забегалов КН, de Abreu MS, Герасимова Е и пр. Towards Zebrafish Models of CNS Channelopathies. International Journal of Molecular Sciences. 2022 Нояб. 12;23(22). 13979. https://doi.org/10.3390/ijms232213979

Author

Колесникова, Татьяна Олеговна ; Демин, Константин Андреевич ; Costa, Fabiano V. ; Забегалов, Константин Николаевич ; de Abreu, Murilo S ; Герасимова, Елена ; Калуев, Алан Валерьевич. / Towards Zebrafish Models of CNS Channelopathies. в: International Journal of Molecular Sciences. 2022 ; Том 23, № 22.

BibTeX

@article{7c03f5b5ec9049b5b20171db219e225c,
title = "Towards Zebrafish Models of CNS Channelopathies",
abstract = "Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl− by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish.",
keywords = "animal model, brain, channelopathy, ion channel, zebrafish",
author = "Колесникова, {Татьяна Олеговна} and Демин, {Константин Андреевич} and Costa, {Fabiano V.} and Забегалов, {Константин Николаевич} and {de Abreu}, {Murilo S} and Елена Герасимова and Калуев, {Алан Валерьевич}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = nov,
day = "12",
doi = "10.3390/ijms232213979",
language = "English",
volume = "23",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI AG",
number = "22",

}

RIS

TY - JOUR

T1 - Towards Zebrafish Models of CNS Channelopathies

AU - Колесникова, Татьяна Олеговна

AU - Демин, Константин Андреевич

AU - Costa, Fabiano V.

AU - Забегалов, Константин Николаевич

AU - de Abreu, Murilo S

AU - Герасимова, Елена

AU - Калуев, Алан Валерьевич

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022/11/12

Y1 - 2022/11/12

N2 - Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl− by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish.

AB - Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl− by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish.

KW - animal model

KW - brain

KW - channelopathy

KW - ion channel

KW - zebrafish

UR - https://www.mendeley.com/catalogue/f472e5d0-b45c-32a2-a657-5eac131df2e0/

UR - http://www.scopus.com/inward/record.url?scp=85142788186&partnerID=8YFLogxK

U2 - 10.3390/ijms232213979

DO - 10.3390/ijms232213979

M3 - Review article

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 22

M1 - 13979

ER -

ID: 100349265